Participation of JAK, STAT and unknown proteins in human placental lactogen-induced signaling: A unique signaling pathway different from prolactin and growth hormone
Participation of JAK, STAT and unknown proteins in human placental lactogen-induced signaling: A unique signaling pathway different from prolactin and growth hormone
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DOI：
10.1677/joe.0.153r001
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发表时间：
1997-04-01
影响因子：
4
通讯作者：
Murata, Y
中科院分区：
文献类型：
--
作者：
Takeda, T;Kurachi, H;Murata, Y
研究了人胎盘催乳素（hPL）的信号转导机制。我们发现 hPL 能快速刺激至少 7 种蛋白质的酪氨酸磷酸化，包括 Janus 激酶（JAK1 和 JAK2）以及转录蛋白信号转导器和激活剂 (Stat3)。这是 JAK-STAT 通路参与 hPL 信号传导的第一个证据。此外，两种大小与 STAT 蛋白（Stat1、3 和 5）不同的未知蛋白主要是酪氨酸磷酸化的。由于人生长激素（hGH）激活Stat1、3、5，人催乳素（hPRL）激活Stat5，这些结果表明hPL使用不同于hGH和hPRL的独特信号转导途径。
The signal transduction mechanism involved in human placental lactogen (hPL) was studied. We have identified that hPL rapidly stimulated the tyrosine phosphorylation of at least 7 proteins including Janus Kinases (JAK1 and JAK2) and a signal transducer and activator of transcription protein (Stat3). This is the first evidence that the JAK-STAT pathway is involved in the hPL signaling. Moreover, two unknown proteins which were different from STAT proteins (Stat1, 3 and 5) in sizes were predominantly tyrosine-phosphorylated. Because human growth hormone (hGH) activates Stat1, 3, 5 and human prolactin (hPRL) activates Stat5, these results show that hPL uses a unique signal transduction pathway which is different from hGH and hPRL.