Excess mortality, causes of death and prognostic factors in anorexia nervosa
Excess mortality, causes of death and prognostic factors in anorexia nervosa
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DOI：
10.1192/bjp.bp.108.054742
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发表时间：
2009-01-01
影响因子：
10.5
通讯作者：
Ekselius, Lisa
中科院分区：
文献类型：
--
作者：
Papadopoulos, Fotios C.;Ekbom, Anders;Ekselius, Lisa
神经性厌食症是一种精神疾病，死亡率高，目的是估计标准化死亡率（SMR），并探讨潜在的预后factor.Method六千零九名妇女谁曾住院治疗神经性厌食症进行了回顾性随访使用瑞典register.Results神经性厌食症的总SMR为6.2（95%CI 5.5-7.0）。神经性厌食症、精神活性物质使用和自杀的SMR最高。几乎所有自然和非自然死亡原因的SMR都显著增加。首次住院后20年或更长时间的SMR仍然很高。在过去的二十年中，死亡率较低。年轻的年龄和较长的住院时间在第一次住院治疗与更好的结果，精神和躯体合并症恶化outcome.Conclusions神经性厌食症的特点是终身死亡率高，自然和非自然的原因。评估和治疗精神共病，特别是酒精滥用，可能是一个更好的长期结果的途径。
Background Anorexia nervosa is a mental disorder with high mortality.Aims To estimate standardised mortality ratios (SMRs) and to investigate potential prognostic factors.Method Six thousand and nine women who had in-patient treatment for anorexia nervosa were followed-up retrospectively using Swedish registers.Results The overall SMR for anorexia nervosa was 6.2 (95% CI 5.5-7.0). Anorexia nervosa, psychoactive substance use and suicide had the highest SMR. The SMR was significantly increased for almost all natural and unnatural causes of death. The SMR 20 years or more after the first hospitalisation remained significantly high. Lower mortality was found during the last two decades. Younger age and longer hospital stay at first hospitalisation was associated with better outcome, and psychiatric and somatic comorbidity worsened the outcome.Conclusions Anorexia nervosa is characterised by high lifetime mortality from both natural and unnatural causes. Assessment and treatment of psychiatric comorbidity, especially alcohol misuse, may be a pathway to better long-term outcome.