The epidemiology of enteric caliciviruses from humans: A reassessment using new diagnostics
The epidemiology of enteric caliciviruses from humans: A reassessment using new diagnostics
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DOI：
10.1086/315588
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发表时间：
2000-05-01
影响因子：
6.4
通讯作者：
Monroe, SS
中科院分区：
文献类型：
--
作者：
Glass, RI;Noel, J;Monroe, SS
在美国，急性胃肠炎是出院记录和死亡证明上最常见的疾病之一，但这些病例中很少有病原学诊断。新的分子诊断方法的应用表明，杯状病毒（以前称为诺瓦克病毒家族或小圆结构病毒）是美国急性胃肠炎（AGE）爆发的最常见原因，它们可能成为儿童和成人散发AGE病例的常见原因。新的分子方法允许疫情菌株追溯到他们的共同来源，并导致了第一次确定的病毒在牵连车辆的感染水，贝类和食品污染的来源和食品处理。这些方法在医院和公共卫生实验室的常规诊断中的广泛应用正在推动我们对杯状病毒相关腹泻的全部负担的认识，并为其预防和控制开辟了新的途径。
In the United States, acute gastroenteritis is one of the most commonly noted illnesses on hospital discharge records and death certificates, yet few of these cases have an etiologic diagnosis. The application of new molecular diagnostic methods has shown caliciviruses (previously referred to as the Norwalk family of viruses or small round structured viruses) to be the most common cause of acute gastroenteritis (AGE) outbreaks in the United States, and they may emerge as a common cause of sporadic cases of AGE among both children and adults. Novel molecular methods have permitted outbreak strains to be traced back to their common source and have led to the first identification of virus in implicated vehicles of infection-water, shellfish, and foods contaminated both at their source and by food handlers. The broad application of these methods to routine diagnosis in hospitals and public health Laboratories is advancing our appreciation of the full burden of calicivirus-associated diarrhea, and it is opening new avenues for its prevention and control.