How short is short? Optimum source-detector distance for short-separation channels in functional near-infrared spectroscopy
How short is short? Optimum source-detector distance for short-separation channels in functional near-infrared spectroscopy
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DOI：
10.1117/1.nph.2.2.025005
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发表时间：
2015-04-01
期刊：
影响因子：
5.3
通讯作者：
Cooper, Robert J.
中科院分区：
文献类型：
--
作者：
Brigadoi, Sabrina;Cooper, Robert J.
近年来，已经证明，使用具有短间隔的功能近红外光谱（fNIRS）通道来明确地对脑外组织进行采样可以显著提高fNIRS测量的准确性和可靠性。这些短分离通道的目的是测量与标准fNIRS通道相同的浅表血流动力学，同时对大脑不敏感。我们使用Monte Carlo模拟光子传输的解剖学告知多层模型，以确定最佳的源探测器的距离短的分离通道在成人和新生儿人群。我们提出了一个查找图，提供（一个可接受的值的短分离通道大脑灵敏度相对于标准通道大脑灵敏度）的最佳短分离距离。虽然值在头皮上不同，但当短间隔通道脑灵敏度与标准通道脑灵敏度的可接受比率设置为5%时，最佳短间隔距离在典型成人中为8.4 mm，在足月婴儿中为2.15 mm。(C)2015年，美国光电仪器工程师学会（SPIE）
In recent years, it has been demonstrated that using functional near-infrared spectroscopy (fNIRS) channels with short separations to explicitly sample extra-cerebral tissues can provide a significant improvement in the accuracy and reliability of fNIRS measurements. The aim of these short-separation channels is to measure the same superficial hemodynamics observed by standard fNIRS channels while also being insensitive to the brain. We use Monte Carlo simulations of photon transport in anatomically informed multilayer models to determine the optimum source-detector distance for short-separation channels in adult and newborn populations. We present a look-up plot that provides (for an acceptable value of short-separation channel brain sensitivity relative to standard channel brain sensitivity) the optimum short-separation distance. Though values vary across the scalp, when the acceptable ratio of the short-separation channel brain sensitivity to standard channel brain sensitivity is set at 5%, the optimum short-separation distance is 8.4 mm in the typical adult and 2.15 mm in the term-age infant. (C) 2015 Society of Photo-Optical Instrumentation Engineers (SPIE)