Medial prefrontal cortex lesions inhibit reflex micturition in anethetized rats
Medial prefrontal cortex lesions inhibit reflex micturition in anethetized rats
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DOI：
10.1016/j.neures.2005.09.005
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发表时间：
2006-01-01
影响因子：
2.9
通讯作者：
Uemura, H
中科院分区：
文献类型：
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作者：
Matsumoto, S;Hanai, T;Uemura, H
根据临床报道的证据，内侧前额叶皮质被认为参与了排尿和尿控的控制，但其确切作用尚不完全清楚。这项研究调查了乌拉坦麻醉大鼠内侧前额叶皮质的鹅膏酸损伤是否会影响容量诱发排尿。分别于前额叶内侧皮质注射鹅膏替酸(0.5mU·g)或赋形剂(0.5mU·L)1周后，以0.1ml/min的速度持续注入生理盐水，记录膀胱收缩的发生率和幅度。与注射前相比，注射赋形剂并没有改变膀胱收缩的发生率或幅度。鹅膏油酸损毁对膀胱收缩幅度无明显影响，但显著延长了膀胱收缩间隔时间。组织学分析显示，鹅膏油酸损毁主要局限于前扣带回和前扣带回皮质。较大的鹅膏酸损伤延伸到下缘皮质腹侧会产生不同的反应，但不会显着改变膀胱收缩的总体发生率或幅度。这些数据表明，内侧前额叶皮质影响膀胱收缩的时间，但不影响收缩幅度。(C)2005年爱思唯尔爱尔兰有限公司和日本神经科学学会。版权所有。
The medial prefrontal cortex is thought to participate in the control of micturition and urinary continence, based on evidence from clinical reports, but its exact role is not fully understood. This study investigated whether ibotenic acid lesions of the medial prefrontal cortex would influence volume-evoked micturition in urethane-anesthetized rats. The incidence and amplitude of bladder contractions were recorded during continuous saline infusion (0.1 ml/min) immediately before and 1 week after ibotenicacid (0.5 mu g) or vehicle (0,5 mu l) was injected into the medial prefrontal cortex. Vehicle injection did not change the incidence or amplitude of bladder contractions compared to pre-injection values. Ibotenic acid lesions prolonged the time interval between bladder contractions significantly although it did not affect the amplitude of bladder contractions, Histological analysis revealed that ibotenic acid lesions were restricted primarily to the anterior cingulate and prelimbic cortices. Larger ibotenic acid lesions extending ventrally into the infralimbic cortex produced a variable response but did not change the overall incidence or amplitude of bladder contractions significantly. These data indicate that the medial prefrontal cortex influences the timing of bladder contractions but does not affect contraction amplitudes. (c) 2005 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.