Recommendations for preclinical research in hemorrhagic transformation.
Recommendations for preclinical research in hemorrhagic transformation.
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DOI:
10.1007/s12975-012-0222-5
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发表时间:
2013-06
影响因子:
6.9
通讯作者:
Ergul, Adviye
中科院分区:
文献类型:
--
作者:
Fagan, Susan C.;Lapchak, Paul A.;Liebeskind, David S.;Ishrat, Tauheed;Ergul, Adviye
关键词:
Hemorrhagic transformation (HT) is an important complication of ischemic stroke and is responsible for most of the mortality associated with acute reperfusion therapy. Although many important publications address the preclinical models of ischemic stroke, there are no current recommendations on the conduct of research aimed at understanding the mechanisms and consequences of HT. The purpose of this review is to present the various models used in HT research, the clinical correlates, and the experimental variables known to influence the quantitation of HT in preclinical investigation. Lastly, recommendations for the conduct of preclinical research in HT are provided.
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