Lingual flange protrusion: diagnostic marker for metastatic liver cancer
Lingual flange protrusion: diagnostic marker for metastatic liver cancer
复制标题
舌侧凸缘突出：转移性肝癌的诊断标志
DOI：
10.1016/s0254-6272(18)30041-4
复制
发表时间：
2017
影响因子：
2.6
通讯作者：
Wu Xiongzhi
中科院分区：
文献类型：
--
作者：
Ma Yinlu;Yang Xue;Zhu Cuihong;Cao Rui;Wu Xiongzhi
目的探讨舌缘突出对恶性肿瘤肝转移的诊断价值。记录所有患者舌象照片，以舌突突出为阳性标准。采用配对资料的χ 2检验和Kappa检验确定舌缘突出对转移性肝癌的诊断价值。采用Mann-Whitney U检验比较肝脏血清学标志物水平。采用受试者工作特征曲线下面积（ROC）和Logistic回归模型分析舌苔突出、碱性磷酸酶（ALP）和乳酸脱氢酶（LDH）水平对肝转移的预测价值。舌缘突出诊断肝转移与传统诊断标准比较差异无统计学意义（P = 0.541）。Kappa值为0.738（P < 0.001）。舌缘前突与血清ALP和LDH水平升高呈显著相关（P < 0.01）。ROC曲线比较显示，舌突前突的诊断价值明显优于ALP、LDH及二者联合检测（P < 0.01）。舌突与ALP、舌突与LDH、舌突与ALP、舌突与LDH的联合诊断价值均不优于舌突单独诊断（P > 0.05）。
ObjectiveTo investigate the diagnostic significance of lingual flange protrusion for liver metastasis of patients with malignant neoplasia.MethodsThe data of 191 patients with malignant neoplasia were analyzed. All photos of patients' tongue image were recorded and lingual flange protrusion was the positive standard. χ2test for paired data and Kappa test were used to determine the diagnostic value of lingual flange protrusion for metastatic liver cancer. Mann-Whitney U test was used to compare the levels of liver serological markers. The area under receiver operating characteristic curve (ROC) and logistic regression model were used to analyze the predictive values of lingual flange protrusion, alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) levels.ResultsPatients with lingual flange protrusion had a higher risk of liver metastasis than those without it (P < 0.001). There was no significant difference in diagnosis of liver metastasis between lingual flange protrusion and traditional diagnostic criteria (P = 0.541). Kappa was 0.738 (P < 0.001). Lingual flange protrusion was significantly correlated with increased serum ALP and LDH levels (P < 0.01). Comparison of ROC curves showed that the diagnostic value of lingual flange protrusion is better than ALP, LDH and the combination of ALP and LDH (P < 0.01). Furthermore, the combined diagnostic values of lingual flange protrusion and ALP, lingual flange protrusion and LDH, and lingual flange protrusion, ALP and LDH are not better than lingual flange protrusion alone (P > 0.05).ConclusionLingual flange protrusion is a potential diagnostic marker for liver metastasis of patients with malignant neoplasia.