A population-based twin study of the relationship between neuroticism and internalizing disorders
A population-based twin study of the relationship between neuroticism and internalizing disorders
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DOI：
10.1176/appi.ajp.163.5.857
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发表时间：
2006-05-01
影响因子：
17.7
通讯作者：
Kendler, KS
中科院分区：
文献类型：
--
作者：
Hettema, JM;Neale, MC;Kendler, KS
目的：焦虑和抑郁障碍表现出高水平的终生共病。作者研究了人格特质神经质和七种内在性障碍所共有的遗传和环境因素如何有助于解释这种共病。方法：通过结构化的诊断性访谈，对9000多对来自男性-男性、女性-女性和异性的双胞胎进行了终生抑郁症、广泛性焦虑症、惊恐障碍、广场恐惧症、社交恐惧症、动物恐惧症、情景恐惧症和神经质的评估。多变量结构方程模型被用来将这些表型之间的相关性分解为遗传和环境因素，考虑到性别特有的因素。结果：遗传因素与神经质有关，占内化性疾病遗传风险的三分之一至一半。从模型中剔除不显著的性别差异后，神经质与每种障碍之间的遗传相关性很高，而特定于个人的环境相关性显著较低。此外，作者可以确定一个神经质独立的遗传因素，它显著增加了严重抑郁、广泛性焦虑症和恐慌症的风险。结论：影响神经质个体差异的遗传因素和那些增加内化性障碍易感性的遗传因素之间存在大量但不完全的重叠，这有助于解释后者的高共病发生率。这可能对识别这些疾病的易感基因具有重要意义。
Objective: The anxiety and depressive disorders exhibit high levels of lifetime comorbidity with one another. The authors examined how genetic and environmental factors shared by the personality trait neuroticism and seven internalizing disorders may help explain this comorbidity.Method: Lifetime major depression, generalized anxiety disorder, panic disorder, agoraphobia, social phobia, animal phobia, situational phobia, and neuroticism were assessed in over 9,000 twins from male-male, female-female, and opposite-sex pairs through structured diagnostic interviews. Multivariate structural equation models were used to decompose the correlations between these phenotypes into genetic and environmental components, allowing for sex-specific factors.Results: Genetic factors shared with neuroticism accounted for between one-third and one-half of the genetic risk across the internalizing disorders. When nonsignificant gender differences were removed from the models, the genetic correlations between neuroticism and each disorder were high, while individual-specific environmental correlations were substantially lower. In addition, the authors could identify a neuroticism-independent genetic factor that significantly increased risk for major depression, generalized anxiety disorder, and panic disorder.Conclusions: There is substantial, but not complete, overlap between the genetic factors that influence individual variation in neuroticism and those that increase liability across the internalizing disorders, helping to explain the high rates of comorbidity among the latter. This may have important implications for identifying the susceptibility genes for these conditions.