Origin and turnover of monocytes and macrophages.
Origin and turnover of monocytes and macrophages.
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DOI：
10.1007/978-3-642-73855-5_6
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
R. Furth
中科院分区：
文献类型：
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作者：
R. Furth
第一次尝试确定巨噬细胞的骨髓起源是在1963年(Balner 1963)。这项研究用小鼠骨髓嵌合体和一种针对捐赠者骨髓细胞的细胞毒性抗体进行，结果表明，在适当的时候，宿主的腹膜巨噬细胞被捐赠者的细胞取代。自那以后，许多研究人员使用不同的标记物遵循了这种方法，所有人都得出了相同的结论，即巨噬细胞来自骨髓中的前体细胞(表1)。其中一些研究是在人类身上进行的，即接受骨髓或肝移植的患者。肝移植患者并不代表真正的嵌合体，但用来自宿主的Kupffer细胞替换供体肝脏中的Kupffer细胞的原理与骨髓移植后用供体细胞替换宿主细胞的原理相同。嵌合体的使用有一个缺点，那就是它们不能代表真正的稳定状态，因为接受放射治疗或细胞毒性药物治疗会引起炎症。
The first attempt to establish the bone marrow origin of macrophages was made in 1963 (Balner 1963). This study, done with mouse bone marrow chimeras and a cytotoxic antibody against the donor bone marrow cells, showed that in due course the peritoneal macrophages of the host were replaced by cells from the donor. This approach has since been followed by many researchers using various markers, and all of them came to the same conclusion, i.e., that macrophages derive from precursor cells in the bone marrow (Table 1). Some of these studies were done in man, i.e., in patients undergoing bone marrow or liver transplantation. Liver transplant patients do not represent true chimeras, but the replacement of the Kupffer cells in the donor liver by Kupffer cells from the host is based on the same principle as the replacement of host cells by donor cells after bone marrow transplantation. The use of chimeras has the drawback that they do not represent the true steady-state condition, because the treatment of the recipients with irradiation or cytotoxic drugs causes inflammation.