Role of Incretin Axis in Inflammatory Bowel Disease.
Role of Incretin Axis in Inflammatory Bowel Disease.
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肠促胰岛素轴在炎症性肠病中的作用
DOI：
10.3389/fimmu.2017.01734
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发表时间：
2017
影响因子：
7.3
通讯作者：
Zhong J
中科院分区：
文献类型：
--
作者：
Duan L;Rao X;Braunstein Z;Toomey AC;Zhong J
炎症性肠病(IBD)包括克罗恩病(CD)和溃疡性结肠炎(UC)，是一种慢性胃肠道炎症性疾病，涉及环境、遗传和免疫因素的复杂相互作用。尽管对IBD免疫学发病机制的基础认识有了很大进展，但IBD病理进展的详细机制仍不清楚。除了Th1/Th2细胞在炎症性肠病中的作用已被明确外，最近的证据表明Th17型 细胞和Treg细胞在炎症性肠病的发生发展中也起着至关重要的作用。含有过量糖、盐和脂肪的饮食也可能是IBD发病的重要因素，这可能是西方发达国家和工业化国家IBD发病率较高的原因。到目前为止，发达国家和发展中国家IBD患病率差异的原因尚不清楚。这在一定程度上是因为西方饮食在发展中国家越来越受欢迎，这使得数据更难解释。肠分泌素类高血糖素肽(GLP-1和GLP-2)在脂代谢、动脉粥样硬化形成、血糖水平和维持胃粘膜完整性等方面具有显著的作用。除了对营养代谢的调节外，GLPs及其降解酶DPP-4在胃肠道疾病中的作用也越来越受到重视。因此，我们就DPP-4/GLP轴在IBD中的作用作一综述。
The inflammatory bowel diseases (IBDs), including Crohn’s disease (CD) and ulcerative colitis (UC), are chronic inflammatory conditions of the gastrointestinal tract and involve a complicated reciprocity of environmental, genetic, and immunologic factors. Despite substantial advances in the foundational understanding of the immunological pathogenesis of IBD, the detailed mechanism of the pathological progression in IBD remains unknown. In addition to Th1/Th2 cells, whose role in IBD has been previously well defined, recent evidence indicates that Th17 cells and Tregs also play a crucial role in the development of IBD. Diets which contain excess sugars, salt, and fat may also be important actors in the pathogenesis of IBD, which may be the cause of high IBD incidence in western developed and industrialized countries. Up until now, the reason for the variance in prevalence of IBD between developed and developing countries has been unknown. This is partly due to the increasing popularity of western diets in developing countries, which makes the data harder to interpret. The enterocrinins glucagon-like peptides (GLPs), including GLP-1 and GLP-2, exhibit notable benefits on lipid metabolism, atherosclerosis formation, plasma glucose levels, and maintenance of gastric mucosa integrity. In addition to the regulation of nutrient metabolism, the emerging role of GLPs and their degrading enzyme dipeptidyl peptidase-4 (DPP-4) in gastrointestinal diseases has gained increasing attention. Therefore, here we review the function of the DPP-4/GLP axis in IBD.
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作者：
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