Simplification and improvement of height-based azithromycin treatment for paediatric trachoma
Simplification and improvement of height-based azithromycin treatment for paediatric trachoma
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DOI：
10.1016/j.trstmh.2004.01.014
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发表时间：
2005-01-01
影响因子：
2.2
通讯作者：
Mecaskey, JW
中科院分区：
文献类型：
--
作者：
Basilion, EV;Kilima, PM;Mecaskey, JW
最近的数据表明，阿奇霉素在比以前记录的剂量更高的剂量下是安全的，这为探索基于高度的儿童沙眼治疗的效率和有效性方面的一些重要改进提供了机会。本研究的目的是检验单一标准化时间表在任何沙眼流行地区应用的可行性。对来自亚洲、北非和撒哈拉以南非洲的 60813 名儿童的数据进行了分析。制定了一个身高计划，最大限度地增加接受 20-40 mg/kg 治疗的儿童数量，这是对小儿沙眼安全有效治疗范围的保守估计。使用标准化时间表，97.7% 的 6 至 59 个月的儿童接受口服混悬剂，96.7% 的 60 个月至 15 岁的儿童接受片剂治疗，剂量范围为 20-40 mg/kg。不到 1% 的儿童接受的治疗剂量低于 20 毫克/公斤。这些发现表明，本文提出的时间表可能会为广泛的易患白色沙眼的人群提供安全有效的治疗，从而大大提高基于身高的治疗的效率。 (C) 2004 年皇家热带医学和卫生学会。由爱思唯尔有限公司出版。保留所有权利。
Recent data showing that azithromycin is safe at higher dosages than previously documented provide an opportunity to explore several important improvements in the efficiency and effectiveness of height-based treatment of paediatric trachoma. The purpose of this study is to examine the feasibility of a single standardised schedule for application in any trachoma-endemic region. Data for 60813 children from Asia, North and sub-Saharan Africa were analysed. A height schedule maximizing the number of children receiving treatment of 20-40 mg/kg, a conservative estimate of the safe and effective treatment range for paediatric trachoma, was developed. Using the standardised schedule, 97.7% of children aged 6 to 59 months receiving oral suspension and 96.7% of children aged 60 months to 15 years receiving tablets would have received treatment within a dosage range of 20-40 mg/kg. Less than 1% of all children would have received treatment less than 20 mg/kg. These findings suggest that the schedule presented in this paper is likely to yield safe and effective treatment for a broad range of populations vulnerable to trachoma white substantially improving the efficiency of height-based treatment. (C) 2004 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.