Seasonal variations in activity of systemic lupus erythematosus in a subarctic region
Seasonal variations in activity of systemic lupus erythematosus in a subarctic region
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DOI：
10.1191/096120399678847858
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发表时间：
1999-01-01
期刊：
影响因子：
2.6
通讯作者：
Wetterberg, L
中科院分区：
文献类型：
--
作者：
Haga, HJ;Brun, JG;Wetterberg, L
光敏性是系统性红斑狼疮（SLE）的主要临床特征之一，被认为与该疾病的发病机制有关。我们研究了北纬 70 度 SLE 疾病活动的季节变化，这里冬天没有阳光，而夏天每天 24 小时都有阳光（午夜阳光）。还研究了6月和12月血浆褪黑素水平与疾病表现之间的关联。21名SLE患者每月进行一次检查，持续1年，通过实验室参数以及临床疾病活动参数SLEDAI和医生的总体评估来评估疾病活动性。褪黑激素水平通过 RIA 测定进行量化。一年内，从一个月到下一个月，疾病活动的临床测量或实验室参数没有显着变化，除了光敏皮疹之外。与今年其他月份相比，一月是唯一没有出现系统性红斑狼疮或关节炎的月份。 7 名患者的血浆褪黑激素水平在 12 月最高，1 名患者的血浆褪黑素水平在 6 月最高（P < 0.005）。血浆褪黑激素水平与临床疾病活动的测量值不相关。在北纬 70 度，一年内 SLE 疾病活动没有重大季节性变化。夏季有光敏性的积累，但冬季没有迹象表明病情恶化。与今年其他月份相比，1 月份没有耀斑，日照时间只有 5.6 小时。 p-褪黑激素的水平与疾病活动度的测量也不相关。
Photosensitivity is one of the major clinical features of Systemic Lupus Erythematosus (SLE), and is considered to be implicated in the disease pathogenesis. We studied seasonal variations of SLE disease activity at latitude 70 degrees North LI here there is no sunlight in the winter time, in contrast to 24 h daily sunlight in the summer (midnight sun). The associations between the level of plasma melatonin in June and December with disease manifestations were also studied.Twenty-one SLE patients were examined each month for 1 y, and disease activity was assessed by laboratory parameters as well as clinical disease activity parameters SLEDAI and doctor's global assessment. Melatonin levels were quantified by a RIA-assay.There was no significant change of clinical measures or laboratory parameters of disease activity from one month to the next during the one year, except photosensitive rashes. January was the only month without SLE-flares or arthritis, in contrast to rest of the year. The levels of plasma melatonin were highest in December for seven patients and highest in June for one patient (P < 0.005). Plasma melatonin levels did not correlate with measures of clinical disease activity.At a latitude of 70 degrees North there were no major seasonal variations in SLE disease activity during the one year. There was an accumulation of photosensitivity in the summer months, but no indications of worsening of the disease in the winter months. In contrast to the rest of the year, there was no flare in January which had only 5.6 h of sunshine. The level of p-melatonin did nor correlate with measures of disease activity.