Cerebrovascular complications of streptokinase infusion.
Cerebrovascular complications of streptokinase infusion.
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链激酶输注的脑血管并发症。
DOI：
10.1001/jama.1985.03350360103029
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
H. Greenberg
中科院分区：
文献类型：
--
作者：
M. Aldrich;S. Sherman;H. Greenberg
回顾性研究了91例使用链激酶治疗血管闭塞的患者，以记录脑出血的发生率。发生3例脑血管并发症。两名患者发生脑出血，一名发生在肢体缺血后，另一名发生在急性心肌梗死后。第3例患者接受链激酶治疗右锁骨下动脉旁路移植术闭塞，发生右额顶叶梗死，可能继发于逆行栓塞，但未通过血管造影证实。脑血管并发症的发生率必须在全身缺血后的基线发生率范围内，但建议谨慎使用这种治疗。
Ninety-one patients treated with streptokinase for vascular occlusion were studied retrospectively to document the incidence of cerebral hemorrhage. Three cerebrovascular complications occurred. Two patients had cerebral hemorrhage, one following limb ischemia, the other after acute myocardial infarction. The third patient received streptokinase for an occluded right subclavian bypass graft and suffered a right frontoparietal infarction, presumably secondary to retrograde embolization, but not angiographically proved. This incidence of cerebrovascular complications must be taken within the framework of the baseline incidence following systemic ischemia, but suggests that caution be exercised with this therapy.