Giant cell tumour of tendon sheath (localised nodular tenosynovitis): clinicopathological features of 71 cases
Giant cell tumour of tendon sheath (localised nodular tenosynovitis): clinicopathological features of 71 cases
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DOI：
10.1136/jcp.54.5.404
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发表时间：
2001-05-01
影响因子：
3.4
通讯作者：
Al-Nafussi, A
中科院分区：
文献类型：
--
作者：
Monaghan, H;Salter, DM;Al-Nafussi, A
腱鞘巨细胞瘤（GCTTS）被认为是手部最常见的肿瘤，切除后可复发。本研究的目的是回顾一系列的情况下，在我们的部门，并确定任何临床或病理特征，可能预测的可能性reproduction. Methods临床数据，从病理学要求的形式和病人的笔记，沿着71例GCTTS的大体和显微镜下表现进行了评价。与以前的研究相比，较高的有丝分裂计数（范围，1-21有丝分裂/10高倍视野（HPF）;平均值，5/10 HPF）在所有情况下，无论复发和大量的凋亡小体（高达30/10 HPF），主要由破骨细胞样巨细胞形成，是present. Conclusions-GCTTS是一个相对罕见的软组织肿瘤的不确定histiogenesis。有丝分裂和凋亡的数字是一个共同的特点，并不表明临床行为。完全局部切除是治疗的首选。
Aims/Background-Giant cell tumour of the tendon sheath (GCTTS) is regarded as the most common neoplasm of the hand that can recur after excision. The objective of this study was to review a series of cases in our department and to determine any clinical or pathological features that might predict the likelihood of recurrence.Methods-Clinical data, obtained from pathology request forms and in patient notes, along with the gross and microscopic appearances of 71 cases of GCTTS were evaluated.Results-Clinical features and pathological features identified were similar to those of previous st-Ladies. in comparison with previous studies a higher mitotic count (range, 1-21 mitoses/10 high power fields (HPF); mean, 5/10 HPF) was noted in all cases, irrespective of recurrence and numerous apoptotic bodies (up to 30/10 HPF), mainly formed from osteoclast-like giant cells, were present.Conclusions-GCTTS is a relatively rare soft tissue tumour of uncertain histiogenesis. Mitotic and apoptotic figures are a common feature and do not indicate clinical behaviour. Complete local excision is the treatment of choice.