Measurements and modelling of the compliance of human and porcine organs
Measurements and modelling of the compliance of human and porcine organs
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DOI：
10.1016/s1361-8415(01)00048-2
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发表时间：
2001-12-01
影响因子：
10.9
通讯作者：
Cuschieri, A
中科院分区：
文献类型：
--
作者：
Carter, FJ;Frank, TG;Cuschieri, A
从动物和人体组织中获得的应力应变数据有几个应用，包括医疗诊断，辅助手术器械设计和生产逼真的基于计算机的模拟器，用于最小进入手术的培训。这样的数据也可以用于证实组织响应的数学模型。本文介绍了使用与微创手术中使用的器械相似的小压头进行离体和体内组织压痕试验获得的数据。此外，均匀应力测试通过指数应力-应变定律提供基本的材料性能数据，以允许使用有限元方法来预测由小压头产生的非均匀应力的响应。使用静态顺应性探针从收获的猪肝和脾获得数据。人类肝脏的数据来自志愿者患者，使用无菌手持顺应性探针进行小的开放手术。所有的结果表明，高度非线性的应力-应变行为。猪脾的弹性模量比猪肝的弹性模量高得多，分别为0.11和4.0MPa。人肝右叶的平均弹性模量约为0.27 MPa。然而，一个患病肝脏的平均模量为0.74 MPa -几乎是刚度的三倍。结果发现，指数应力-应变法可以准确地拟合均匀应力测试数据，随后的有限元建模的非均匀应力周围的一个小压头匹配测得的力的特性。(C)2001 Elsevier Science B. V.保留所有权利。
Stress-strain data obtained from animal and human tissue have several applications including medical diagnosis, assisting in surgical instrument design and the production of realistic computer-based simulators for training in minimal access surgery. Such data may also be useful for corroborating mathematical models of tissue response. This paper presents data obtained from ex-vivo and in-vivo tissue indentation tests using a small indentor that is similar to instruments used in minimal access surgery. In addition, uniform stress tests provide basic material property data, via an exponential stress-strain law, to allow a finite element method to be used to predict the response for the non-uniform stresses produced by the small indentor. Data are obtained from harvested pig liver and spleen using a static compliance probe. Data for human liver are obtained from volunteer patients, undergoing minor open surgery, using a sterile hand-held compliance probe. All the results demonstrate highly non-linear stress-strain behaviour. Pig spleen is shown to be much more compliant than pig liver with mean elastic moduli of 0.11 and 4.0 MPa respectively. The right lobe of human liver had a mean elastic modulus of about 0.27 MPa. However, a single case of a diseased liver had a mean modulus of 0.74 MPa - nearly three times the stiffness. It was found that an exponential stress-strain law could accurately fit uniform stress test data and that subsequent finite element modelling for non-uniform stress around a small indentor matched measured force characteristics. (C) 2001 Elsevier Science B.V. All rights reserved.