The effect of bilateral cold block of the primate face primary somatosensory cortex on the performance of trained tongue-protrusion task and biting tasks.
The effect of bilateral cold block of the primate face primary somatosensory cortex on the performance of trained tongue-protrusion task and biting tasks.
复制标题
灵长类面部初级体感皮层双侧冷块对训练的伸舌任务和咬任务表现的影响。
作者：
L. D. Lin;G. M. Murray;B. Sessle
1.使用消融，皮质内微刺激（ICMS）和表面刺激，和单神经元记录的研究表明，灵长类动物的初级躯体感觉皮层（SI）可能在运动控制中发挥重要作用。我们的目的是确定是否双边失活的脸SI确实会干扰舌头或下颌闭合运动的控制。2.可逆失活的影响，通过冷却的脸SI进行了研究，在两只猴子训练，以执行舌头伸出任务和咬任务。通过系统地定义记录在面SI中的单个神经元的机械感受野，在识别SI内的口面表征之后进行冷却实验。通过猴子完成这两项任务的成功率以及从咬肌、颏舌肌和二腹肌记录的与任务相关的力和肌电图（EMG）活动来评估舌头或下颌闭合运动的缺陷。3.在面部S1的双侧冷却期间，与用于冷却面部S1的恒温器保持在37摄氏度的对照系列试验相比，舌头伸出任务的成功率在统计学上显著降低。对力和EMG活动的详细分析表明，主要缺陷是猴子在每次试验期间的力保持期间无法保持稳定的舌前伸力，并且在不同试验之间无法施加一致的舌前伸力。在复温开始后4分钟，任务性能恢复到对照方案水平。4.相同的冷却条件并没有显着影响的成功率为性能的咬任务。虽然赤字的程度是不够严重，导致显着降低成功率的咬任务，冷却显着影响猴子的能力，以保持稳定的力量，在每次试验期间，并在不同的试验之间施加一致的力量。在一只猴子中，咬任务的成功率也不受面部SI的双侧冷却的影响，面部SI的大部分、面部初级运动皮质（面部MI）和相邻皮质区域的硬脑膜上放置了一对较大的热电极。（400字处截断摘要）
1. Studies using ablation, intracortical microstimulation (ICMS) and surface stimulation, and single-neuron recordings have suggested that the primate primary somatosensory cortex (SI) may play an important role in movement control. Our aim was to determine whether bilateral inactivation of face SI would indeed interfere with the control of tongue or jaw-closing movements. 2. Effects of reversible inactivation by cooling of face SI was investigated in two monkeys trained to perform both a tongue-protrusion task and a biting task. The cooling experiments were carried out after the orofacial representation within SI was identified by systematically defining the mechanoreceptive field of single neurons recorded in face SI. The deficits in the tongue or jaw-closing movement were evaluated by the success rates for the monkeys' performance of both tasks and by the force and electromyographic (EMG) activity recorded from the masseter, genioglossus, and digastric muscles associated with the tasks. 3. During bilateral cooling of face SI, there was a statistically significant reduction in the success rates for the performance of the tongue-protrusion task in comparison with control series of trials while the thermodes used to cool face SI were kept at 37 degrees C. Detailed analyses of force and EMG activity showed that the principal deficit was the inability of the monkeys to maintain a steady tongue-protrusive force in the force holding period during each trial and to exert a consistent tongue-protrusion force between different trials. The task performance returned to control protocol levels at 4 min after commencement of rewarming. 4. Identical cooling conditions did not significantly affect the success rates for the performance of the biting task. Although the extent of the deficit was not severe enough to cause a significant reduction in successful rates for the biting task, cooling did significantly affect the ability of the monkeys to maintain a steady force in the holding period during each trial and to exert a consistent force between different trials. In one monkey the success rate of the biting task was also not affected by bilaterally cooling of face SI with a pair of larger thermodes placed on the dura over most of the face SI, face primary motor cortex (face MI), and adjacent cortical regions.(ABSTRACT TRUNCATED AT 400 WORDS)