Constitutive type I interferon modulates homeostatic balance through tonic signaling.
Constitutive type I interferon modulates homeostatic balance through tonic signaling.
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DOI：
10.1016/j.immuni.2012.01.011
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发表时间：
2012-02-24
期刊：
影响因子：
32.4
通讯作者：
Levy DE
中科院分区：
文献类型：
--
作者：
Gough DJ;Messina NL;Clarke CJ;Johnstone RW;Levy DE
Interferons (IFNs) were discovered nearly 60 years ago as a family of cytokines induced during and protecting from viral infection. They have been documented to play essential roles in numerous physiological processes beyond innate antiviral defense, including immunomodulation, regulation of the cell cycle, cell survival and differentiation, and the host response to microbial pathogens. Recent data have also uncovered a potentially darker side to the functions of IFN, including roles in autoimmunity and diabetes. Many IFN effects occur in the absence of acute viral infection, highlighting a physiologic role for constitutively produced IFN. Type I IFNs are constitutively produced at vanishingly low quantities and yet exert profound effects, mediated at least in part through modulation of signaling intermediates required for diverse cytokine response pathways. We review evidence for a yin-yang of IFN function through its role in modulating crosstalk between multiple cytokines by both feed-forward and feed-back regulation of common signaling intermediates and postulate that a similar mechanism underlies a homeostatic role for IFN through tonic signaling in the absence of acute infection.
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发表时间：
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期刊：
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影响因子：
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通讯作者：
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