Histologic findings in normal breast tissues: comparison to reduction mammaplasty and benign breast disease tissues
Histologic findings in normal breast tissues: comparison to reduction mammaplasty and benign breast disease tissues
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DOI：
10.1007/s10549-011-1746-1
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发表时间：
2012-05-01
影响因子：
3.8
通讯作者：
Hartmann, Lynn C.
中科院分区：
文献类型：
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作者：
Degnim, Amy C.;Visscher, Daniel W.;Hartmann, Lynn C.
乳腺癌发生的研究通常依赖于癌组织和非恶性乳腺组织的比较。目前尚不清楚非恶性乳腺组织的常见参考来源如何反映正常乳腺组织。乳腺组织样本从三个来源进行评估：(1)印第安纳大学西蒙癌症中心（KTB） Susan G. Komen for the Cure（A (R)）组织库的正常供体组织，(2)罗切斯特梅奥诊所接受缩小乳房成形术（RM）的妇女，(3)梅奥诊所良性乳房疾病队列研究（BBD）。对样本进行组织学检查，并评估增生疾病和小叶退化程度。在各研究组之间进行单因素比较，并使用逻辑回归进行多因素分析，以评估研究组与上皮增生性疾病和完全小叶退化的存在之间的关系。收集了455例KTB样本、259例RM样本和319例BBD样本的组织学数据。各组间组织学表现及上皮细胞增殖频率差异有统计学意义。组织学异常见于少数KTB样本（35%），而异常存在于88%的RM组织和97.5%的BBD样本中。在3.3%的正常供体（3.3%）、17%的RM样本和34.9%的BBD样本中存在增殖性疾病（伴有或不伴有非典型增生）（每次比较的P < 0.0001）。多变量分析证实，这些差异仍然显著，并且还显示，与RM和BBD组织相比，正常供体样本中小叶完全退化的可能性更高。与良性乳腺疾病组织和乳腺缩小成形术组织相比，来自正常供体的乳腺组织样本的组织学异常明显减少，小叶复旧的发生率更高。来自正常供体的乳腺组织样本是一种独特的组织资源，其组织学特征与较低的乳腺癌风险相一致。
Investigations of breast carcinogenesis often rely upon comparisons between cancer tissue and nonmalignant breast tissue. It is unclear how well common reference sources of nonmalignant breast tissues reflect normal breast tissue. Breast tissue samples were evaluated from three sources: (1) normal donor tissues in the Susan G. Komen for the Cure(A (R)) Tissue Bank at Indiana University Simon Cancer Center (KTB), (2) women who underwent reduction mammaplasty (RM) at Mayo Clinic Rochester, and (3) the Mayo Clinic Benign Breast Disease Cohort Study (BBD). Samples were examined histologically and assessed for proliferative disease and degree of lobular involution. Univariate comparisons were performed among the study groups, and multivariate analyses were performed with logistic regression to assess the association between study group and the presence of epithelial proliferative disease and complete lobular involution. Histologic data were collected for 455 KTB samples, 259 RM samples, and 319 BBD samples. Histologic findings and the frequency of epithelial proliferation were significantly different among the groups. Histologic abnormalities were seen in a minority of the KTB samples (35%), whereas an abnormality was present in 88% of RM tissues and 97.5% of BBD samples. The presence of proliferative disease (with or without atypical hyperplasia) was present in 3.3% of normal donors (3.3%), 17% of RM samples, and 34.9% of BBD samples (P < 0.0001 for each comparison). Multivariate analyses confirmed that these differences remained significant and also showed higher likelihood of complete lobular involution in the normal donor samples compared to RM and BBD tissues. Compared to benign breast disease tissues and reduction mammaplasty tissues, breast tissue samples from normal donors have significantly fewer histologic abnormalities and a higher frequency of more complete lobular involution. Breast tissue samples from normal donors represent a unique tissue resource with histologic features consistent with lower breast cancer risk.