How can the microbiologist help in diagnosing neonatal sepsis?
How can the microbiologist help in diagnosing neonatal sepsis?
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DOI：
10.1155/2012/120139
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发表时间：
2012
影响因子：
2.1
通讯作者：
Sambri V
中科院分区：
文献类型：
--
作者：
Paolucci M;Landini MP;Sambri V
根据症状发作是在出生后 72 小时之前（早发性新生儿败血症 —EONS）还是晚发性新生儿败血症（晚发性新生儿败血症 —LONS），新生儿败血症可分为两种亚型。这些定义通过确定哪些微生物可能导致这些时期的败血症以及感染的预期结果，对诊断和治疗做出了巨大贡献。本文重点介绍微生物学家可以提供的诊断并最终预防新生儿败血症的工具。在这里，我们讨论血培养的优点和局限性，血培养是脓毒症诊断的实际金标准。此外，我们还研究了分子技术在新生儿败血症诊断和治疗中的实用性。
Neonatal sepsis can be classified into two subtypes depending upon whether the onset of symptoms is before 72 hours of life (early-onset neonatal sepsis—EONS) or later (late-onset neonatal sepsis—LONS). These definitions have contributed greatly to diagnosis and treatment by identifying which microorganisms are likely to be responsible for sepsis during these periods and the expected outcomes of infection. This paper focuses on the tools that microbiologist can offer to diagnose and eventually prevent neonatal sepsis. Here, we discuss the advantages and limitation of the blood culture, the actual gold standard for sepsis diagnosis. In addition, we examine the utility of molecular techniques in the diagnosis and management of neonatal sepsis.