Molecular ablation of ventricular tachycardia after myocardial infarction
Molecular ablation of ventricular tachycardia after myocardial infarction
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DOI：
10.1038/nm1503
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发表时间：
2006-11-01
期刊：
影响因子：
82.9
通讯作者：
Donahue, J. Kevin
中科院分区：
文献类型：
--
作者：
Sasano, Tetsuo;McDonald, Amy D.;Donahue, J. Kevin
室性心动过速是心肌梗死后常见的致死性并发症。在这里，我们表明，在猪模型中，将编码显性负性KCNH 2钾通道（KCNH 2-G628 S）的基因转移到梗死瘢痕边缘消除了所有室性心律失常。未发现致心律失常或其他不良反应。我们的研究结果表明，基因治疗消融室性心律失常的潜在可行性。
Ventricular tachycardia is a common and lethal complication after myocardial infarction. Here we show that focal transfer of a gene encoding a dominant-negative version of the KCNH2 potassium channel ( KCNH2-G628S) to the infarct scar border eliminated all ventricular arrhythmias in a porcine model. No proarrhythmia or other negative effects were discernable. Our results demonstrate the potential viability of gene therapy for ablation of ventricular arrhythmias.