Effects of supplemental dietary arginine, canola oil, and trace elements on cellular immune function in critically injured patients.
Effects of supplemental dietary arginine, canola oil, and trace elements on cellular immune function in critically injured patients.
复制标题
补充膳食精氨酸、菜籽油和微量元素对危重患者细胞免疫功能的影响。
DOI：
10.1097/00024382-199607000-00003
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Maier,RV
中科院分区：
文献类型：
--
作者：
Mendez,C;Jurkovich,GJ;Wener,MH;Garcia,I;Mays,M;Maier,RV
膳食营养素在调节免疫系统方面可能具有药理学价值。我们研究了两种肠内饮食对危重创伤患者免疫功能的影响，这两种饮食的精氨酸含量、脂肪来源和选择的微量元素不同。在接受标准饮食或实验饮食的第一、第六和第十天，从健康志愿者和严重损伤（ISS> 13）的患者中分离白细胞。内毒素暴露后，测定单核细胞的肿瘤坏死因子、促凝血活性和前列腺素E2。评估了神经元氧化物产生和淋巴细胞胚细胞生成。与正常患者相比，白细胞功能在第1天被一致抑制。接受实验饮食的患者的白细胞反应在第6天得到改善或“正常化”，而接受标准饮食的患者的白细胞反应仍然受到抑制。饮食营养调整可以影响严重损伤患者对炎症刺激的细胞免疫反应。
Dietary nutrients may have pharmacological value in modulating the immune system. We studied the effects of two enteral diets, which differed in their content of arginine, fat source, and select trace elements, on immune function in critically injured patients. Leukocytes were isolated from healthy volunteers and severely injured (ISS> 13) patients on the first, sixth, and tenth day of receiving either a standard diet or experimental diet. Monocytes were assayed for tumor necrosis factor, procoagulant activity, and prostaglandin E 2 following endotoxin exposure. Neutrophil oxidant production and lymphocyte blastogenesis was assessed. Leukocyte function was uniformly depressed compared to normal patients on day 1. The response of leukocytes from patients receiving experimental diet improved or “normalized” by day 6, while remaining depressed in patients receiving standard diet. Dietary nutrient modification can effect cellular immune responses to inflammatory stimuli in severely injured patients.