Lack of Specificity of Anticyclic Citrullinated Peptide Antibodies in Advanced Human Immunodeficiency Virus Infection
Lack of Specificity of Anticyclic Citrullinated Peptide Antibodies in Advanced Human Immunodeficiency Virus Infection
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DOI：
10.3899/jrheum.100713
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发表时间：
2011-06-01
影响因子：
3.9
通讯作者：
Esser, Monika
中科院分区：
文献类型：
--
作者：
du Toit, Riette;Whitelaw, David;Esser, Monika
客观的。确定人类免疫缺陷病毒（HIV）感染中类风湿性关节炎（RA）的抗环瓜氨酸肽抗体（抗CCP）和类风湿因子（RF）的流行率和特异性，并评估免疫重建对这些标记物的影响。方法。没有关节炎的晚期 HIV 感染患者被纳入研究。在开始抗逆转录病毒治疗 (ART) 之前测定 CD4+ T 淋巴细胞计数 (CD4)、抗 CCP 和 RF，并在 6 个月后重复测定。将结果与健康对照的结果进行比较。对患者 RA 的发展情况进行了一年的随访。结果。对 60 名患者和 26 名对照进行了研究。 49 名患者获得了 6 个月的随访结果。与对照组相比，HIV 患者抗 CCP 的平均 (SD) 水平较高：分别为 9.50 (11.41) 和 0.80 (1.32) 单位 (p
Objective. To determine the prevalence and specificity of anticyclic citrullinated peptide antibodies (anti-CCP) and rheumatoid factor (RF) for rheumatoid arthritis (RA) in human immunodeficiency virus (HIV) infection and to evaluate the effect of immune reconstitution on these markers.Methods. Patients with advanced HIV infection without arthritis were enrolled. CD4+ T lymphocyte counts (CD4), anti-CCP, and RF were determined before initiating antiretroviral therapy (ART) and repeated after 6 months. Results were compared to those of healthy controls. Patients were followed for the development of RA for I year.Results. Sixty patients and 26 controls were studied. Six-month followup results were available on 49 patients. Mean (SD) levels of anti-CCP were higher in patients with HIV compared to controls: respectively, 9.50 (11.41) versus 0.80 (1.32) units (p