Cell death and growth arrest in response to photodynamic therapy with membrane-bound photosensitizers
Cell death and growth arrest in response to photodynamic therapy with membrane-bound photosensitizers
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DOI：
10.1016/s0006-2952(03)00539-2
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发表时间：
2003-10-15
影响因子：
5.8
通讯作者：
Agostinis, P
中科院分区：
文献类型：
--
作者：
Piette, J;Volanti, C;Agostinis, P
光动力疗法（PDT）是一种治疗癌症和某些良性疾病的方法，其基于使用光敏剂和光在细胞中产生活性氧。目前用于PDT的许多光敏剂定位于不同的细胞区室，如线粒体、溶酶体、内质网，并通过触发坏死和/或凋亡产生细胞死亡。当光、氧和光敏剂不受限制时（“高剂量PDT”），观察到有效的细胞死亡。当这些组分之一是限制性的（“低剂量PDT”）时，大多数细胞不会立即经历凋亡或坏死，而是生长停滞，几种转导途径被激活。本文就两种重要的光动力疗法药物介导的细胞凋亡和生长阻滞的机制作一综述。即焦脱镁叶绿酸和金丝桃素。(C)2003年爱思唯尔公司All rights reserved.
Photodynamic therapy (PDT) is a treatment for cancer and for certain benign conditions that is based on the use of a photosensitizer and light to produce reactive oxygen species in cells. Many of the photosensitizers currently used in PDT localize in different cell compartments such as mitochondria, lysosomes, endoplasmic reticulum and generate cell death by triggering necrosis and/or apoptosis. Efficient cell death is observed when light, oxygen and the photosensitizer are not limiting ("high dose PDT"). When one of these components is limiting ("low dose PDT"), most of the cells do not immediately undergo apoptosis or necrosis but are growth arrested with several transduction pathways activated. This commentary will review the mechanism of apoptosis and growth arrest mediated by two important PDT agents. i.e. pyropheophorbide and hypericin. (C) 2003 Elsevier Inc. All rights reserved.