Relationship of Neurovascular Elements to Neuron Injury during Ischemia
Relationship of Neurovascular Elements to Neuron Injury during Ischemia
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DOI：
10.1159/000200442
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发表时间：
2009-01-01
影响因子：
2.9
通讯作者：
del Zoppo, Gregory J.
中科院分区：
文献类型：
--
作者：
del Zoppo, Gregory J.
流向脑区的血流阻塞识别出处于危险中的血管区域内的脆弱区域，这些区域合并成为成熟的缺血性病变。大量不成功的临床试验集中在人类的神经元和血管外靶点上，这些靶点在临床前模型中显示出明显的挽救作用。然而，观察到微血管和神经元对缺血的反应同时发生在这些区域，这表明反应可以协调。本报告探讨了支持“神经血管单位”概念的证据及其在缺血性卒中急性干预试验中的应用。有没有统一的原因，非血管干预，作为一个类别，在临床试验中没有成功，但临床观察和假设都意味着需要了解与神经血管单位的相互作用作为进一步的神经元保护剂试验的前奏。版权所有（C）2009 S. Karger AG，巴塞尔
Occlusion of flow to the brain regions identifies regions of vulnerability within the vascular territory at risk, which coalesce to become the mature ischemic lesion. A large number of unsuccessful clinical trials have focused on neuron and extravascular targets in humans that have shown apparent salvage in preclinical models. However, the observation that microvessel and neuron responses to ischemia occur simultaneously in these regions suggest that the responses could be coordinated. This presentation examines evidence in support of the conceptual 'neurovascular unit' and its application to the setting of acute intervention trials in ischemic stroke. There are no uniform reasons for which nonvascular interventions, as a class, have not been successful in clinical trials, but both the clinical observations and the hypothesis imply the need to understand interactions with the neurovascular unit as a prelude to further neuron protectant trials. Copyright (C) 2009 S. Karger AG, Basel