Cardiovascular risk factors and inflammatory activity among centenarians with and without dementia
Cardiovascular risk factors and inflammatory activity among centenarians with and without dementia
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DOI：
10.1007/s40520-016-0603-9
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发表时间：
2017-06-01
影响因子：
4
通讯作者：
Lima, Nereida K. C.
中科院分区：
文献类型：
--
作者：
Duarte, Paulo de O.;Duarte, Mariana G. F.;Lima, Nereida K. C.
更好地了解那些保持认知能力到100岁或以上的人与那些出现痴呆综合症的同龄人之间存在的差异，可能有助于了解老年痴呆症。本研究的目的是评估患有和不患有痴呆症的百岁老人的心血管危险因素和炎症标志物。本文对居住在某中等城市的百岁老人进行了以人口为基础的横断面研究。在家中对志愿者进行综合老年评估。进行一般实验室检查，并确定心血管风险和炎症活动标志物。受试者平均年龄为101±2岁，82%为女性。对痴呆综合征的评估显示，36.4%的百岁老人保持了认知能力。老年痴呆百岁老人受教育程度较低（p < 0.01），体重指数较低（p = 0.02），同型半胱氨酸水平较高（p < 0.01），收缩压较低（p = 0.05）。在炎症活性指标方面，与未患痴呆症的百岁老人相比，痴呆患者的白细胞介素-6、高敏c反应蛋白（p = 0.02）、红细胞沉降率（p = 0.01）水平较高，白蛋白水平较低（p = 0.02）。综上所述，与痴呆受试者相比，保持认知能力的百岁老人具有更好的营养状况、较低的同型半胱氨酸血症、较高的血压倾向和较低的炎症活性。
A better knowledge of the differences existing between individuals who maintain cognition up to 100 years of age or more and those of the same age who present dementia syndrome may be of help in understanding the dementia of the very elderly people. The aim of this study was to assess cardiovascular risk factors and inflammatory markers among centenarians with and without dementia. A population-based cross-sectional study was conducted on centenarians residing in a middle-size city. Volunteers were evaluated by comprehensive geriatric assessment at home. General laboratory examinations were performed and cardiovascular risk and inflammatory activity markers were determined. Mean subject age was 101 +/- 2 years, and 82 % were women. Assessment of dementia syndrome revealed that 36.4 % of the centenarians had preserved cognition. Centenarians with dementia had lower schooling (p < 0.01), lower body mass index (p = 0.02) and higher homocysteine levels (p < 0.01) and tended to have a lower systolic blood pressure (p = 0.05). Regarding the markers of inflammatory activity, demented subjects had high levels of interleukin-6 (p < 0.01), high-sensitivity C-reactive protein (p = 0.02), and erythrocyte sedimentation rate (p = 0.01) and lower albumin levels (p = 0.02) compared to centenarians without dementia. Concluding, centenarians with preserved cognition had better nutritional status, lower homocysteinemia, tendency to higher blood pressure and lower inflammatory activity compared to demented subjects.