ESTRIOL IN THE TREATMENT OF POSTMENOPAUSAL URGENCY - A MULTICENTER STUDY
ESTRIOL IN THE TREATMENT OF POSTMENOPAUSAL URGENCY - A MULTICENTER STUDY
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DOI：
10.1016/0378-5122(93)90028-g
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发表时间：
1993-12-01
期刊：
影响因子：
4.9
通讯作者：
WALTER, S
中科院分区：
文献类型：
--
作者：
CARDOZO, L;REKERS, H;WALTER, S
绝经后妇女的雌激素缺乏被认为是下尿路症状，特别是“冲动综合征”的重要原因。然而，支持在有症状的绝经后妇女中使用雌激素治疗的证据是有限的。雌三醇是一种弱的、天然存在的雌激素，可能对泌尿生殖系统组织有益而不刺激子宫内膜。我们研究了雌三醇在治疗绝经后感觉性和运动性急迫性尿失禁中的应用。材料和方法：进行了一项双盲、安慰剂对照、随机、多中心研究，口服3 mg雌三醇/天，持续3个月，治疗女性急迫性尿失禁。结果和结论：64名妇女被招募到这项研究。虽然雌三醇在主观和客观上都能改善下尿路功能，但并不明显优于安慰剂。进行多中心研究时遇到了一些困难。
Oestrogen deficiency in postmenopausal women is thought to be important in the genesis of lower urinary tract symptoms, in particular the 'urge syndrome'. Evidence to support the use of oestrogen therapy in symptomatic postmenopausal women is, however, limited. Oestriol is a weak, naturally occurring oestrogen that may be beneficial to the urogenital tissues without stimulating the endometrium. We have investigated the use of oestriol in the treatment of postmenopausal sensory and motor urge incontinence. Materials and methods: A double-blind, placebo-controlled, randomised, multicentre study of 3 mg oral oestriol/day for 3 months in the treatment of women with urge incontinence was undertaken. Results and conclusions: Sixty-four women were recruited into the study. Although oestriol produced both subjective and objective improvement in lower urinary tract function, it was not significantly better than placebo. Some of the difficulties of running a multicentre study were encountered.