Evaluation of gellan gum fluid gels as modified release oral liquids
Evaluation of gellan gum fluid gels as modified release oral liquids
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DOI：
10.1016/j.ijpharm.2014.08.044
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发表时间：
2014-11-20
影响因子：
5.8
通讯作者：
Smith, Alan M.
中科院分区：
文献类型：
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作者：
Mahdi, Mohammed H.;Conway, Barbara R.;Smith, Alan M.
对于吞咽困难的患者，口服液体通常是首选的药物管理方法，然而，制定改良的释放版本可能具有挑战性。在口服液体中实现修饰释放的潜在途径是通过在凝胶形成的生物聚合物凝胶过程中引入剪切场而形成的流体（剪切）凝胶。这些流体凝胶可以作为可浇注的粘弹性流体，但保留了真正的凝胶微纳米结构。在这里，我们已经证明液体凝胶有潜力作为儿科口服液，防止布洛芬在模拟胃液中的释放。随后在pH 7.4下的释放受暴露时间和酸性pH值大小的影响，释放开始与先前的酸性暴露时间呈线性关系。延迟释放是凝胶硬度增加的结果，是初始释放介质的酸度和暴露时间的结果。在酸中暴露时间为10 min比60 min时释放速度快得多。这项研究强调了设计流体凝胶的潜力，这些流体凝胶在特定的pH值和暴露时间下具有特定的刚度。这可以使口服液体的制备具有改变的释放行为。(C) 2014 Elsevier b.v.版权所有
Oral liquids are often preferred for drug administration to patients for whom swallowing is difficult, however, formulating modified release versions can be challenging. A potential route to achieve modified release in oral liquids is by using fluid (sheared) gels formed by introducing a shear field during gelation in gel-forming biopolymers. These fluid gels can act as pourable viscoelastic fluids but retain true gel micro/nano structure. Here, we have demonstrated that fluid gels have potential as paediatric oral liquids preventing release of ibuprofen in simulated gastric fluid. Subsequent release at pH 7.4 was affected by the duration of exposure and magnitude of acid pH with a linear relationship between onset of release and the preceding acidic exposure duration. Delayed release was a result of increasing gel stiffness, a consequence of the acidity of the initial release media and exposure time. A much faster release rate was measured when exposure time in acid was 10 min compared with 60 min. This study highlights the potential to design fluid gels that are tuned to have a specified stiffness at a particular pH and exposure time. This could enable the preparation oral liquids with modified release behaviour. (C) 2014 Elsevier B. V. All rights reserved.