Nasally inhaled dornase alfa in the postoperative management of chronic sinusitis due to cystic fibrosis
Nasally inhaled dornase alfa in the postoperative management of chronic sinusitis due to cystic fibrosis
复制标题
DOI：
10.1001/archotol.126.5.581
复制
发表时间：
2000-05-01
影响因子：
--
通讯作者：
Bent, JP
中科院分区：
文献类型：
--
作者：
Raynor, EM;Butler, A;Bent, JP
目的：探讨鼻腔吸入多糖酶治疗囊性纤维性鼻窦炎的疗效。设计：回顾分析鼻腔吸入多糖酶α与非多糖酶治疗囊性纤维化性鼻窦炎患者的术后病程、放射学检查及肺功能检查结果。在接受功能性鼻内窥镜手术的20名患者中，有5名患者在接受鼻内窥镜手术后开始了鼻腔吸入阿尔法的治疗。地点：三级护理学术中心。结果：在连续3年的内窥镜检查中，接受阿尔法治疗的患者与未接受阿尔法治疗的患者相比，黏膜水肿和息肉都较少。接受鼻腔吸入多糖酶α的患者也较少接受翻修功能性鼻内窥镜手术(1.6比3.2)，尽管这些患者的肺功能测试结果基本上没有变化。结论：鼻窦炎仍然是CF患者的主要发病原因。有症状的患者经常需要多种药物方案，包括长期的全身抗生素治疗，局部和全身类固醇治疗，以及抗生素鼻腔冲洗。这项初步研究表明，鼻腔吸入多糖酶α对控制慢性鼻窦炎术后症状有潜在影响。
Objective: To determine the benefit of nasally inhaled dornase alia in cystic fibrosis (CF) sinusitis.Design: Retrospective chart review comparing postsurgical course, radiographic studies, and pulmonary function test results in patients who were treated with nasally inhaled dornase alfa with those in patients who were not treated with dornase alfa.Patients: Twenty consecutive patients with CF who underwent functional endoscopic sinus surgery from 1993 to 1997 were included in the study. Treatment with nasally inhaled dornase alfa was initiated in 5 of the 20 patients after they underwent functional endoscopic sinus surgery.Setting: Tertiary care academic center.Results: The dornase alfa-treated patients had less mucosal edema and no polyps at serial endoscopy over 3 years compared with the non-dornase alfa-treated patients. The patients who received nasally inhaled dornase alfa also underwent fewer revision functional endoscopic sinus surgical procedures (1.6 vs 3.2), even though there was essentially no change in pulmonary function test results in these patients.Conclusions: Sinusitis continues to be a major cause of morbidity in patients with CF. Symptomatic patients frequently require multiple drug regimens, including longterm systemic antibiotic therapy, topical and systemic steroid therapy, and antibiotic nasal irrigations. This preliminary study indicates the potential impact of nasally inhaled dornase alfa in controlling postoperative symptoms in CF sinusitis.