Comparative genome analysis of Bacillus cereus group genomes with Bacillus subtilis
Comparative genome analysis of Bacillus cereus group genomes with Bacillus subtilis
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DOI：
10.1016/j.femsle.2005.07.008
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发表时间：
2005-09-15
影响因子：
2.1
通讯作者：
Ivanova, N
中科院分区：
文献类型：
--
作者：
Anderson, I;Sorokin, A;Ivanova, N
蜡样芽孢杆菌组基因组的基因组特征（蜡样芽孢杆菌、炭疽芽孢杆菌和苏云金芽孢杆菌亚种的代表性菌株）israelensis）进行分析并与枯草芽孢杆菌基因组进行比较。四个芽孢杆菌基因组中的1381个蛋白质家族的核心集合，以及B共有的933个家族的额外集合。cereus group，被鉴定。在信号转导途径，膜转运蛋白，细胞表面结构，细胞壁和S-层蛋白的差异，表明其表型的差异进行了鉴定。B。蜡状芽孢杆菌群具有包括与来自枯草B的双组分系统组氨酸激酶相关的酪氨酸激酶的信号转导系统。一个调节应激反应因子σ（B）的模型，该因子在B中表达。cereus组与B中已研究的调控不同。subtilis已经提出。尽管在这些基因组中存在高度的染色体同线性，但已经确定了细胞壁和孢子外壳蛋白的显着差异，这些差异有助于在特定宿主中的生存和适应。(c)2005年，欧洲微生物学会联合会。Elsevier B. V.出版，保留所有权利。
Genome features of the Bacillus cereus group genomes (representative strains of Bacillus cereus, Bacillus anthracis and Bacillus thuringiensis sub spp. israelensis) were analyzed and compared with the Bacillus subtilis genome. A core set of 1381 protein families among the four Bacillus genomes, with an additional set of 933 families common to the B. cereus group, was identified. Differences in signal transduction pathways, membrane transporters, cell surface structures, cell wall, and S-layer proteins suggesting differences in their phenotype were identified. The B. cereus group has signal transduction systems including a tyrosine kinase related to two-component system histidine kinases from B subtilis. A model for regulation of the stress responsive sigma factor sigma(B) in the B. cereus group different from the well studied regulation in B. subtilis has been proposed. Despite a high degree of chromosomal synteny among these genomes, significant differences in cell wall and spore coat proteins that contribute to the survival and adaptation in specific hosts has been identified. (c) 2005 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.