Mitochondrial oxidative stress drives tumor progression and metastasis: should we use antioxidants as a key component of cancer treatment and prevention?
Mitochondrial oxidative stress drives tumor progression and metastasis: should we use antioxidants as a key component of cancer treatment and prevention?
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线粒体氧化应激驱动肿瘤进展和转移：我们是否应该使用抗氧化剂作为癌症治疗和预防的关键组成部分？
DOI：
10.1186/1741-7015-9-62
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发表时间：
2011-05-23
期刊：
影响因子：
9.3
通讯作者：
Lisanti MP
中科院分区：
文献类型：
--
作者：
Sotgia F;Martinez-Outschoorn UE;Lisanti MP
氧化应激在癌症发病机制中的作用一直是一个激烈争论的话题。Goh等人本月在BMC Cancer上发表的一项研究，通过建立人类乳腺癌的小鼠动物模型，使用分子遗传学方法直接解决了这一问题。更具体地说，通过靶向线粒体的过氧化氢酶（一种抗氧化酶）的转基因过表达来缓解线粒体氧化应激，足以降低肿瘤级别（从高到低）并显着降低转移性肿瘤负荷>12倍。在这里，我们讨论了这些新的发现，并将它们放在最近的几项研究的背景下，这些研究表明氧化应激直接有助于肿瘤的进展和转移。这些结果具有重要的临床和转化意义，因为大多数当前的化疗药物和放射治疗都会增加氧化应激，因此可能有助于推动肿瘤复发和转移。同样，化疗和放疗都会增加继发性恶性肿瘤的风险，如白血病和/或淋巴瘤。为了有效地减少线粒体氧化应激，医学肿瘤学家现在应该重新考虑使用强效抗氧化剂作为患者治疗和癌症预防的关键组成部分。请参阅相关研究文章：http://www.biomedcentral.com/1471-2407/11/191
The functional role of oxidative stress in cancer pathogenesis has long been a hotly debated topic. A study published this month in BMC Cancer by Goh et al., directly addresses this issue by using a molecular genetic approach, via an established mouse animal model of human breast cancer. More specifically, alleviation of mitochondrial oxidative stress, via transgenic over-expression of catalase (an anti-oxidant enzyme) targeted to mitochondria, was sufficient to lower tumor grade (from high-to-low) and to dramatically reduce metastatic tumor burden by >12-fold. Here, we discuss these new findings and place them in the context of several other recent studies showing that oxidative stress directly contributes to tumor progression and metastasis. These results have important clinical and translational significance, as most current chemo-therapeutic agents and radiation therapy increase oxidative stress, and, therefore, could help drive tumor recurrence and metastasis. Similarly, chemo- and radiation-therapy both increase the risk for developing a secondary malignancy, such as leukemia and/or lymphoma. To effectively reduce mitochondrial oxidative stress, medical oncologists should now re-consider the use of powerful anti-oxidants as a key component of patient therapy and cancer prevention. Please see related research article: http://www.biomedcentral.com/1471-2407/11/191
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影响因子：
3.6
作者：
Mercier I;Casimiro MC;Wang C;Rosenberg AL;Quong J;Minkeu A;Allen KG;Danilo C;Sotgia F;Bonuccelli G;Jasmin JF;Xu H;Bosco E;Aronow B;Witkiewicz A;Pestell RG;Knudsen ES;Lisanti MP
通讯作者：
Lisanti MP
影响因子：
3.8
作者：
Goh J;Enns L;Fatemie S;Hopkins H;Morton J;Pettan-Brewer C;Ladiges W
通讯作者：
Ladiges W
影响因子：
4.3
作者：
Martinez-Outschoorn, Ubaldo E.;Whitaker-Menezes, Diana;Lisanti, Michael P.
通讯作者：
Lisanti, Michael P.
影响因子：
4.3
作者：
Martinez-Outschoorn, Ubaldo E.;Pavlides, Stephanos;Sotgia, Federica
通讯作者：
Sotgia, Federica
影响因子：
6.4
作者：
BRAVARD, A;SABATIER, L;DUTRILLAUX, B
通讯作者：
DUTRILLAUX, B