AMPK: a target for drugs and natural products with effects on both diabetes and cancer.
AMPK: a target for drugs and natural products with effects on both diabetes and cancer.
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作者：
Hardie DG
amp活化蛋白激酶（AMPK）是一种高度保守的细胞能量传感器，似乎在真核生物进化的早期阶段就出现了。2001年，它被证明可以被二甲双胍激活，二甲双胍是目前治疗2型糖尿病的主要药物。虽然已知的AMPK活化的代谢作用与它介导二甲双胍的一些治疗益处的观点是一致的，但正如下面所讨论的，现在看来AMPK不太可能是该药的唯一靶点。AMPK也被几种从传统药物中提取的天然植物产物激活，并讨论了它们激活AMPK的机制。其中之一是水杨酸盐，可能是人类已知的最古老的药物。水杨酸前药水杨酸已被证明可以改善胰岛素抵抗和前驱糖尿病患者的代谢参数，并讨论了这是否可能部分由AMPK介导。有趣的是，有证据表明二甲双胍和阿司匹林对人类癌症的发展都有一定的保护作用，AMPK是否可能参与了这些作用也被讨论了。
The AMP-activated protein kinase (AMPK) is a highly conserved sensor of cellular energy that appears to have arisen at an early stage during eukaryotic evolution. In 2001 it was shown to be activated by metformin, currently the major drug for treatment for type 2 diabetes. Although the known metabolic effects of AMPK activation are consistent with the idea that it mediates some of the therapeutic benefits of metformin, as discussed below it now appears unlikely that AMPK is the sole target of the drug. AMPK is also activated by several natural plant products derived from traditional medicines, and the mechanisms by which they activate AMPK are discussed. One of these is salicylate, probably the oldest medicinal agent known to humankind. The salicylate prodrug salsalate has been shown to improve metabolic parameters in subjects with insulin resistance and prediabetes, and whether this might be mediated in part by AMPK is discussed. Interestingly, there is evidence that both metformin and aspirin provide some protection against development of cancer in humans, and whether AMPK might be involved in these effects is also discussed.
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影响因子：
--
作者：
Hawley SA;Boudeau J;Reid JL;Mustard KJ;Udd L;Mäkelä TP;Alessi DR;Hardie DG
通讯作者：
Hardie DG
AMP激活的蛋白激酶对ULK1（HATG1）的磷酸化将能量传感连接到线粒体。
DOI：
10.1126/science.1196371
发表时间：
2011-01-28
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Egan DF;Shackelford DB;Mihaylova MM;Gelino S;Kohnz RA;Mair W;Vasquez DS;Joshi A;Gwinn DM;Taylor R;Asara JM;Fitzpatrick J;Dillin A;Viollet B;Kundu M;Hansen M;Shaw RJ
通讯作者：
Shaw RJ
DOI：
10.1126/science.1215327
发表时间：
2012-05-18
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Hawley SA;Fullerton MD;Ross FA;Schertzer JD;Chevtzoff C;Walker KJ;Peggie MW;Zibrova D;Green KA;Mustard KJ;Kemp BE;Sakamoto K;Steinberg GR;Hardie DG
通讯作者：
Hardie DG
DOI：
10.1111/j.1432-1033.1990.tb15293.x
发表时间：
1990-01-12
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
DAVIES, SP;SIM, ATR;HARDIE, DG
通讯作者：
HARDIE, DG
影响因子：
4.8
作者：
El-Mir, MY;Nogueira, V;Leverve, X
通讯作者：
Leverve, X