Expression of HSPF1 and LIM in the lymphoblastoid cells derived from patients with bipolar disorder and schizophrenia
Expression of HSPF1 and LIM in the lymphoblastoid cells derived from patients with bipolar disorder and schizophrenia
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DOI：
10.1007/s10038-004-0136-5
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发表时间：
2004-05-01
影响因子：
3.5
通讯作者：
Kato, T
中科院分区：
文献类型：
--
作者：
Iwamoto, K;Bundo, M;Kato, T
我们以前曾报道过HSPF1和LIM的表达改变的淋巴母细胞系（LCL）来自日本患者的双相情感障碍（双相I型障碍）。在LCL水平上改变的表达将有助于开发双相情感障碍的诊断标志物以及细胞模型。在这项研究中，我们通过使用以下样本测量它们的表达来扩展我们先前的研究：（1）来自日本受试者的大量LCL，（2）来自高加索受试者的LCL，和（3）来自双相II型障碍或精神分裂症患者的LCL。我们证实了日本I型双相情感障碍患者LCL中HSPF1的表达增加（P=0.009）和LIM的表达减少（P=0.001）。在日本双相II型障碍患者中也观察到这些改变的表达（HSP 1 P=0.002，LIM P=0.072）。我们还发现HSPF1在白人双相II型障碍患者LCL中的表达改变（P=0.011），在精神分裂症患者LIM中的表达改变（P=0.001）。
We have previously reported the altered expressions of HSPF1 and LIM in the lymphoblastoid cell lines (LCLs) derived from Japanese patients with bipolar disorder (bipolar I disorder). The altered expression at the LCL level would be useful for developing diagnostic markers as well as a cellular model for bipolar disorder. In this study, we extended our previous study by measuring their expressions using the following samples: (1) larger number of LCLs from Japanese subjects, (2) LCLs from Caucasian subjects, and (3) LCLs from patients with bipolar II disorder or schizophrenia. We confirmed the increased expression of HSPF1 (P=0.009) and decreased expression of LIM (P=0.001) in the LCLs from patients with Japanese bipolar I disorder. These altered expressions were also observed in those from patients with Japanese bipolar II disorder (P=0.002 for HSPF1 and P=0.072 for LIM). We also found the altered expressions of HSPF1 in LCLs from Caucasian patients with bipolar II disorder (P=0.011) and LIM in those from patients with schizophrenia (P=0.001).