VACCINATION AGAINST HEPATITIS-B - COMPARISON OF 3 DIFFERENT VACCINATION SCHEDULES
VACCINATION AGAINST HEPATITIS-B - COMPARISON OF 3 DIFFERENT VACCINATION SCHEDULES
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DOI：
10.1093/infdis/160.5.766
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发表时间：
1989-11-01
影响因子：
6.4
通讯作者：
DEINHARDT, F
中科院分区：
文献类型：
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作者：
JILG, W;SCHMIDT, M;DEINHARDT, F
在89名健康年轻人中比较了在0、1、2、12个月、0、1、6个月或0、1、12个月注射三种不同的乙肝疫苗接种方案。第三次注射后乙型肝炎表面抗原抗体（anti-HBs）的浓度取决于第二次和第三次注射之间的间隔；在第2个月、第6个月和第12个月给药时，三组的几何平均滴度（GMTs）分别为53 IU/l、5,846 IU/l和19,912 IU/l。尽管在第6个月或第12个月第三次剂量的抗hbs反应是典型的增强反应，但在第2个月给予第三次剂量后的动力学与仅两次剂量后的动力学相似，但水平明显更高。在第12个月给第0、1和2个月接种疫苗的人第四剂疫苗，在高度上迅速产生了与第0、1和12个月接种疫苗的人相似的抗hbs反应。因此，为了获得高的抗hbs浓度，保证其持久存在，在第0、1和12个月接种疫苗似乎比在第0、1和6个月接种疫苗更可取。对于乙型肝炎感染高危人群，可考虑在0、1、2和12个月接种疫苗，以获得最佳的早期血清转化和长期保护。
Three different hepatitis B vaccination schedules employing injections at months 0, 1, 2, an 12, at months 0, 1, and 6, or at months 0, 1, and 12 were compared in 89 healthy young adults. Concentrations of antibodies to hepatitis B surface antigen (anti-HBs) after the third injection were dependent on the interval between the second and the third dose; geometric mean titers (GMTs) in the three groups were 53 IU/l, 5,846 IU/l, and 19,912 IU/l, respectively, when the third dose was given at month 2, 6, or 12. Whereas the anti-HBs responses to the third dose at month 6 or 12 were typical booster reactions, the kinetics after a third dose given at month 2 resembled those after only two doses but on a significantly higher level. A fourth dose given at month 12 to the individuals vaccinated at months 0, 1, and 2 led to a prompt anti-HBs response similar in height to the response in those vaccinated at months 0, 1, and 12. Thus, for achieving a high anti-HBs concentration guaranteeing its long-lasting persistence, vaccination at months 0, 1, and 12 seems to be preferable to vaccination at months 0, 1, and 6. For individuals at high risk of hepatitis B infection, vaccination at months 0, 1, 2, and 12 might be considered for obtaining an optimal early seroconversion as well as long-term protection.