Alcohol consumption and endometrial cancer risk: the multiethnic cohort.
Alcohol consumption and endometrial cancer risk: the multiethnic cohort.
复制标题
饮酒和子宫内膜癌风险：多种族队列。
DOI：
10.1002/ijc.23072
复制
发表时间：
2008
影响因子：
6.4
通讯作者：
Henderson,BrianE
中科院分区：
文献类型：
--
作者：
Setiawan,VeronicaWendy;Monroe,KristineR;Goodman,MarcT;Kolonel,LaurenceN;Pike,MalcolmC;Henderson,BrianE
The role of alcohol intake in the etiology of endometrial cancer is unclear. We examined the impact of alcohol intake on endometrial cancer risk among 41,574 postmenopausal African‐American, Japanese‐American, Latina, Native‐Hawaiian and White women recruited to the prospective Multiethnic Cohort Study in 1993–1996. During an average of 8.3 years of follow‐up, 324 incident invasive endometrial cancer cases were identified among these women. Data on alcohol intake and endometrial cancer risk factors were obtained from the baseline questionnaire. Relative risks (RRs) and 95% confidence intervals (CIs) for endometrial cancer associated with alcohol intake were estimated using log‐linear (Cox) proportional hazard models stratified by age, year of recruitment, ethnicity and study center, and adjusted for several confounding factors. Increased alcohol consumption was associated with increased risk (ptrend = 0.013). Compared to nondrinkers, women consuming ≥2 drinks/day had a multivariate RR of 2.01 (95% CI: 1.30, 3.11). There was no increase in risk associated with <1 drink/day (RR = 1.01; 95% CI: 0.77, 1.33) and 1 to <2 drinks/day (RR = 1.09; 95% CI: 0.62, 1.93). There was no clear effect modification by body mass index, postmenopausal hormone use, parity, oral contraceptive use or smoking status, though our power to detect such interactions was limited. Our results suggest that only alcohol consumption equivalent to 2 or more drinks per day increases risk of endometrial cancer in postmenopausal women. © 2007 Wiley‐Liss, Inc.
