The Golden Retriever Lifetime Study: establishing an observational cohort study with translational relevance for human health.
The Golden Retriever Lifetime Study: establishing an observational cohort study with translational relevance for human health.
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DOI：
10.1098/rstb.2014.0230
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发表时间：
2015-07-19
期刊：
影响因子：
--
通讯作者：
Brown DE
中科院分区：
文献类型：
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作者：
Guy MK;Page RL;Jensen WA;Olson PN;Haworth JD;Searfoss EE;Brown DE
金毛寻回犬寿命研究（GRLS）是兽医学中第一项前瞻性纵向研究，旨在确定犬癌症和其他重要疾病的主要饮食，遗传和环境风险因素。GRLS是一项观察性研究，将通过狗主人的年度在线问卷以及初级保健兽医的年度体检和生物样本收集来跟踪3000只纯种金毛猎犬的一生。比较医学研究宠物中自然发生的疾病的领域与动物和人类疾病的遗传基础有关，包括癌症，失明，代谢和行为障碍以及一些神经退行性疾病。GRLS为几种疾病类别的转化比较医学倡议提供高质量数据的机会是巨大的。特别是，有机会开发生活方式和活动，环境暴露和饮食史的终身数据集，结合同步的年度生物样本集和详细的健康结果，将为这个地理上分散的狗群提供疾病发病率数据，并与各种潜在风险因素相关联。GRLS将提供一生的历史背景，重复的生物样本集和结果，以询问基因和环境影响与癌症之间的复杂关联。
The Golden Retriever Lifetime Study (GRLS) is the first prospective longitudinal study attempted in veterinary medicine to identify the major dietary, genetic and environmental risk factors for cancer and other important diseases in dogs. The GRLS is an observational study that will follow a cohort of 3000 purebred Golden Retrievers throughout their lives via annual online questionnaires from the dog owner and annual physical examinations and collection of biological samples by the primary care veterinarian. The field of comparative medicine investigating naturally occurring disorders in pets is specifically relevant to the many diseases that have a genetic basis for disease in both animals and humans, including cancer, blindness, metabolic and behavioural disorders and some neurodegenerative disorders. The opportunity for the GRLS to provide high-quality data for translational comparative medical initiatives in several disease categories is great. In particular, the opportunity to develop a lifetime dataset of lifestyle and activity, environmental exposure and diet history combined with simultaneous annual biological sample sets and detailed health outcomes will provide disease incidence data for this cohort of geographically dispersed dogs and associations with a wide variety of potential risk factors. The GRLS will provide a lifetime historical context, repeated biological sample sets and outcomes necessary to interrogate complex associations between genes and environmental influences and cancer.