Monkeypox zoonotic associations: Insights from laboratory evaluation of animals associated with the multi-state us outbreak
Monkeypox zoonotic associations: Insights from laboratory evaluation of animals associated with the multi-state us outbreak
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DOI：
10.4269/ajtmh.2007.76.757
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发表时间：
2007-04-01
影响因子：
3.3
通讯作者：
Regnery, Russell L.
中科院分区：
文献类型：
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作者：
Hutson, Christina L.;Lee, Kemba N.;Regnery, Russell L.
在2003年美国猴痘爆发之初，没有关于哪些动物种属参与病毒输入和/或随后传播给人类以及在北美是否存在建立人畜共患猴痘的风险的病毒学数据。同样，目前还不清楚哪些标本最适合进行病毒检测。在至少33只动物中检测到猴痘DNA，并从22只动物中培养出病毒。病毒阳性动物包括与输入事件相关的三种非洲物种（巨袋鼠，仓鼠属;绳松鼠，Funisciuris sp.;和睡鼠，Graphiuris sp.）。来自北美草原犬鼠（Cynomys sp.）的病毒学证据与它们作为人类猴痘载体的可疑作用一致。发现多种组织适合于DNA检测和/或病毒分离。这些数据扩大了猴痘病毒感染的潜在宿主范围，并支持有关在新的宿主物种和生态系统中建立的可能性的担忧。
At the onset of the 2003 US monkeypox outbreak, virologic data were unavailable regarding which animal species were involved with virus importation and/or subsequent transmission to humans and whether there was a risk for establishment of zoonotic monkeypox in North America. Similarly, it was unclear which specimens would be best for virus testing. Monkeypox DNA was detected in at least 33 animals, and virus was cultured from 22. Virus-positive animals included three African species associated with the importation event (giant pouched rats, Cricetomys spp.; rope squirrels, Funisciuris sp.; and dormice, Graphiuris sp.). Virologic evidence from North American prairie dogs (Cynomys sp.) was concordant with their suspected roles as vectors for human monkeypox. Multiple tissues were found suitable for DNA detection and/or virus isolation. These data extend the potential host range for monkeypox virus infection and supports concern regarding the potential for establishment in novel reservoir species and ecosystems.