Inactivation of Lon protease reveals a link between mitochondrial unfolded protein stress and mitochondrial translation inhibition.
Inactivation of Lon protease reveals a link between mitochondrial unfolded protein stress and mitochondrial translation inhibition.
复制标题
Lon 蛋白酶的失活揭示了线粒体未折叠蛋白应激和线粒体翻译抑制之间的联系。
DOI：
10.1038/s41419-018-1213-6
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发表时间：
2018
影响因子：
9
通讯作者：
Pallanck,LeoJ
中科院分区：
文献类型：
--
作者：
Pareek,Gautam;Pallanck,LeoJ
线粒体未折叠蛋白反应 (UPRmt) 通路通过激活促进蛋白质折叠和降解的因子，提供针对错误折叠和聚集蛋白质的保护。我们最近对 Lon 蛋白酶的研究表明，线粒体翻译抑制也可能是 UPRmt 通路的一个特征，Lon 蛋白酶是与多种细胞活性相关的线粒体 ATP 酶 (AAA+) 家族的成员。
The mitochondrialUnfoldedProteinResponse (UPRmt) pathway confers protection from misfolded and aggregated proteins by activating factors that promote protein folding and degradation. Our recent work on Lon protease, a member of the mitochondrialATPaseAssociated with diverse cellularActivities (AAA+) family of mitochondrial resident proteases, suggests that mitochondrial translational inhibition may also be a feature of the UPRmtpathway.