PHOTOTOXICITY OF THE TETRACYCLINES - PHOTOSENSITIZED EMISSION OF SINGLET DELTA DIOXYGEN
PHOTOTOXICITY OF THE TETRACYCLINES - PHOTOSENSITIZED EMISSION OF SINGLET DELTA DIOXYGEN
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DOI：
10.1073/pnas.83.13.4604
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发表时间：
1986-07-01
影响因子：
11.1
通讯作者：
KHAN, AU
中科院分区：
文献类型：
--
作者：
HASAN, T;KHAN, AU
报道了四环素类光敏单重态氧在室温氧化溶液中1268 nm发射光谱的观察。在去环素、四环素和米诺环素系列中，单线态产氧的效率与临床观察到的这些抗生素的相对光毒性频率相吻合，提示单线态产氧是其光毒性的来源。
The spectroscopic observation of 1268-nm emission of singlet oxygen photosensitized by tetracyclines in oxygenated solutions at room temperature is reported. In the series demeclocycline, tetracycline, and minocycline, the efficiency of singlet oxygen generation is found to parallel the clinical observation of relative frequency of phototoxicity of these antibiotics, suggesting singlet oxygen generation as the origin of their phototoxicity.