18FDG uptake associated with CT density on PET/CT in lungs with and without chronic interstitial lung diseases
18FDG uptake associated with CT density on PET/CT in lungs with and without chronic interstitial lung diseases
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DOI：
10.1007/s12149-009-0234-8
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发表时间：
2009-03
影响因子：
2.6
通讯作者：
Kentaro Inoue;K. Okada;Y. Taki;R. Goto;S. Kinomura;H. Fukuda
中科院分区：
文献类型：
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作者：
Kentaro Inoue;K. Okada;Y. Taki;R. Goto;S. Kinomura;H. Fukuda
目的正电子发射断层扫描(PET/CT)CT图像的依赖密度与18F-脱氧葡萄糖(18FDG)摄取增加时，有时很难与慢性间质性肺疾病(ILD)鉴别。虽然18FDG-PET对活动期ILD的诊断可能有用，但在没有急性进展的体征和症状的ILD患者中，18FDG轻度摄取的临床相关性尚未被描述。本研究旨在探讨正常肺和临床稳定的慢性ILD患者18FDG摄取与肺密度的关系。方法对36例正常肺(对照组)和28例无急性加重的慢性ILD(ILD)患者进行了18FDG-PET/CT检查。在肺上放置椭圆形感兴趣区(ROI)。结果对照组和ILD组CT密度与18FDG摄取呈线性相关，两者的回归斜率无差异，而ILD组CT密度和18FDG摄取均值较高，两者重叠。结论肺18FDG摄取反映了正常肺组织密度对重力的依赖。尽管慢性ILD患者的肺18FDG摄取和CT密度往往较高，但在某些病例中，可能很难区分正常依赖区和与慢性ILD相关的区域。
ObjectiveThe dependent-density of computed tomography (CT) images of positron emission tomography (PET)/CT is sometimes difficult to distinguish from chronic interstitial lung disease (ILD) when it accompanies increased18F-fluorodeoxy-d-glucose (18FDG) uptake. Though the possible utility of18FDG-PET for the diagnosis of active ILD has been reported, the clinical relevance of mild lung18FDG uptake in ILD cases without signs and symptoms suggesting acute progression has not been described. This study aimed to test relationships between18FDG uptake and lung density on CT using PET/CT in patients with normal lung as well as clinically stable chronic ILD.MethodsThirty-six patients with normal lungs (controls) and 28 patients with chronic ILD (ILD cases) without acute exacerbation were retrospectively selected from18FDG-PET/CT scans performed in examination of malignant neoplasms. Elliptical regions of interest (ROIs) were placed on the lung. The relationships between CT density and18FDG uptake between the control and ILD cases were tested.ResultsThe CT density and18FDG uptake had a linear correlation in both the controls and the ILD cases without a difference in their regression slopes, and they were overlapped between the controls and the ILD cases with higher mean values in the ILD cases.ConclusionsLung18FDG uptake was considered to reflect a gravity-dependent tissue density in the normal lung. Though the lung18FDG uptake as well as the CT density tended to be higher in chronic ILD patients, it may be difficult to distinguish them in normal dependent regions from those related to chronic ILD in some cases.