Rhinovirus infections in myelosuppressed adult blood and marrow transplant recipients
Rhinovirus infections in myelosuppressed adult blood and marrow transplant recipients
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DOI：
10.1086/598627
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发表时间：
1999-09-01
影响因子：
11.8
通讯作者：
Whimbey, E
中科院分区：
文献类型：
--
作者：
Ghosh, S;Champlin, R;Whimbey, E
关于鼻病毒感染在免疫功能低下患者中的临床意义的数据很少。我们回顾了22例因鼻病毒感染而导致骨髓抑制的成人血液和骨髓移植受者的临床过程和结果，这些受者在M，D。安德森癌症中心（休斯顿），1992年1月至1997年1月。在15名患者（68%）中，疾病仍然局限于上呼吸道。7例患者（32%）发生致死性肺炎。这些患者在症状发作后平均12天（范围，3-21天）出现严重呼吸衰竭。在这7例中的6例中，鼻病毒在死亡前从支气管肺泡灌洗液标本和/或气管内吸出物中分离出来。5例患者进行了尸检，其中1例显示播散性曲霉菌病，4例显示间质性肺炎和/或急性呼吸窘迫综合征，无其他微生物。总之，鼻病毒感染可能与严重骨髓抑制免疫功能低下患者相当大的肺相关发病率和死亡率相关。
Scant data are available on the clinical significance of rhinovirus infections in immunocompromised patients. We reviewed the clinical courses of and outcomes for 22 myelosuppressed adult blood and marrow transplant recipients with rhinovirus infections who were hospitalized at the M, D. Anderson Cancer Center (Houston) from January 1992 to January 1997. In 15 patients (68%), illnesses remained confined to the upper respiratory tract. Seven patients (32%) developed fatal pneumonia. These patients had profound respiratory failure a mean of 12 days (range, 3-21 days) after the onset of symptoms. In six of these seven cases, rhinovirus was isolated before death from a bronchoalveolar lavage fluid specimen and/or an endotracheal aspirate. Five patients underwent autopsies, one of which revealed disseminated aspergillosis and four of which revealed interstitial pneumonitis and/or acute respiratory distress syndrome and no other organisms. In conclusion, rhinovirus infections may be associated with considerable pulmonary-related morbidity and mortality in severely myelosuppressed immunocompromised patients.