Effect of peripherally and cortically evoked swallows on jaw reflex responses in anesthetized rabbits.
Effect of peripherally and cortically evoked swallows on jaw reflex responses in anesthetized rabbits.
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外周和皮质诱发吞咽对麻醉兔子下颌反射反应的影响。
DOI：
10.1016/j.brainres.2018.05.002
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发表时间：
2018
期刊：
影响因子：
2.9
通讯作者：
Inoue M.
中科院分区：
文献类型：
--
作者：
Suzuki T;Yoshihara M;Sakai S;Tsuji K;Nagoya K;Magara J;Tsujimura T;Inoue M.
本研究的目的是调查是否下颌开放（JOR）和下颌关闭反射（JCR）调制不仅在外周，而且在中央，诱发吞咽。实验在24只成年雄性日本白色家兔上进行。以1 Hz刺激三叉神经30 s诱发JORs。在中期10 s，同时刺激上级喉神经（SLN）或皮质吞咽区（Cx）诱发吞咽。峰-峰JOR幅度在10-s中期和后期降低（即，在SLN或Cx刺激期间和之后），并且减少依赖于SLN/Cx刺激的电流强度：更大的SLN/Cx刺激电流导致更大的JOR抑制。Cx刺激期间的减少率显著高于SLN刺激期间。SLN/Cx刺激10 s后2 min振幅恢复至基线水平。SLN和Cx共同刺激的作用明显大于单独刺激SLN。两种条件下JCR的任何参数均无显著差异。这些结果清楚地表明，JOR反应被显着抑制，不仅在外周诱发的吞咽，但也在中枢诱发的吞咽，和抑制作用可能是更大的中枢相比，外周诱发的吞咽。这些结果的功能影响进行了讨论。
This study aimed to investigate whether the jaw-opening (JOR) and jaw-closing reflexes (JCR) are modulated during not only peripherally, but also centrally, evoked swallowing. Experiments were carried out on 24 adult male Japanese white rabbits. JORs were evoked by trigeminal stimulation at 1 Hz for 30 s. In the middle 10 s, either the superior laryngeal nerve (SLN) or cortical swallowing area (Cx) was simultaneously stimulated to evoke swallowing. The peak-to-peak JOR amplitude was reduced during the middle and late 10-s periods (i.e., during and after SLN or Cx stimulation), and the reduction was dependent on the current intensity of SLN/Cx stimulation: greater SLN/Cx stimulus current resulted in greater JOR inhibition. The reduction rate was significantly greater during Cx stimulation than during SLN stimulation. The amplitude returned to baseline 2 min after 10-s SLN/Cx stimulation. The effect of co-stimulation of SLN and Cx was significantly greater than that of SLN stimulation alone. There were no significant differences in any parameters of the JCR between conditions. These results clearly showed that JOR responses were significantly suppressed, not only during peripherally evoked swallowing but also during centrally evoked swallowing, and that the inhibitory effect is likely to be larger during centrally compared with peripherally evoked swallowing. The functional implications of these results are discussed.