Motor learning of hands with auditory cue in patients with Parkinson's disease
Motor learning of hands with auditory cue in patients with Parkinson's disease
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DOI：
10.1007/s00702-005-0314-4
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发表时间：
2006-02-01
影响因子：
3.3
通讯作者：
Mano, Y
中科院分区：
文献类型：
--
作者：
Chuma, T;Reza, MF;Mano, Y
在本研究中，观察了帕金森氏病(PD)患者和正常对照受试者在重复的、随意的拇指运动(训练)过程中运动皮质功能的变化。采用应变计对12例帕金森病患者和9例正常对照进行了运动训练后经颅磁刺激(TMS)诱发的运动诱发电位(MEP)对拇指运动方向的影响。经历冰冻现象的帕金森病患者自我调步运动后，TMS诱发的运动方向变化不明显，但在听觉提示训练后，TMS诱发的运动方向发生了显著变化。没有经历过冰冻现象的帕金森病患者在听觉提示下表现出积极的效果，产生的结果与正常对照组相似。神经系统中有两条自主运动的途径。帕金森病所致的基底节功能减退损害了从基底节到辅助运动皮质的通路。这些数据表明，从感觉输入到小脑到运动前皮质的通路可以补偿通过基底节到运动前皮质的通路功能的下降。一旦运动皮质发生变化，即使训练中断，这种变化也会持续下去。这些现象表明，运动记忆可以储存在运动皮质中。
In the present research, changes in motor cortex function were observed in relation to repetitive, voluntary thumb movement (training) in patients with Parkinson's disease (PD) and normal control subjects. Changes in the direction of thumb movement due to motor evoked potential (MEP) by transcranial magnetic stimulation (TMS), after motor training with and without rhythmic sound, were measured using a strain gauge for 12 patients with PD and 9 normal control subjects. PD patients who experienced the freezing phenomena showed poor change in direction of TMS-induced movement after self-paced movement; however, marked change in direction of TMS-induced movement was observed after training with auditory cue. PD patients who had not experienced the freezing phenomena showed positive effects with the auditory cue, producing similar results as the normal control subjects. Two routes for voluntary movement are available in the nervous system. The decreased function of basal ganglia due to PD impaired the route from the basal ganglia to the supplementary motor cortex. These data suggest that the route from sensory input to cerebellum to premotor cortex could compensate for the decreased function of the route via the basal ganglia to the premotor cortex. Once change in the motor cortex occurred, such change persisted even after the interruption of training. These phenomena suggest that motor memory can be stored in the motor cortex.