Salivary uric acid: Associations with resting and reactive blood pressure response to social evaluative stress in healthy African Americans.
Salivary uric acid: Associations with resting and reactive blood pressure response to social evaluative stress in healthy African Americans.
复制标题
唾液尿酸：与健康非裔美国人的静息血压和反应性血压对社会评价压力的反应相关。
DOI：
10.1016/j.psyneuen.2018.10.025
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发表时间：
2019
影响因子：
3.7
通讯作者：
Granger,DouglasA
中科院分区：
文献类型：
--
作者：
Woerner,Jacqueline;Lucas,Todd;Pierce,Jennifer;Riis,JennaL;Granger,DouglasA
高水平的尿酸与压力相关的心血管疾病的风险更大有关，这些疾病在非洲裔美国人中不成比例地发生。高尿酸血症是否会影响急性应激的生物学反应仍不清楚，这表明需要澄清这种潜在的联系。目前的研究探讨了唾液尿酸（sUA）如何与静息和反应性血压相关-这是高血压和相关心血管疾病和差异的两个可靠预测因素。健康的非裔美国人（N= 107; 32%男性;法师= 31.74岁），完成了特里尔社会压力测试，以诱导社会评价压力。在任务之前、期间和之后记录收缩压和舒张压读数，以评估血压的静息和反应性变化。参与者还提供了一份基线唾液样本，用于测定sUA。在休息时，控制年龄，sUA与较高的收缩压（r= 0.201，p = 0.044）适度相关，但与舒张压（r= 0.100，p = 0.319）无关。在对应激任务的反应中，再次控制年龄，sUA也与收缩压（r= 0.219，p = 0.025）和舒张压（r= 0.198，p <0.044）的较高总激活相关。随后的适度分析表明，女性的sUA和BP测量之间的关联是显着的，但不为男性。研究结果表明，尿酸可能与高血压和心血管健康差异有关，这与急性社会压力引起的血压升高有关，低水平的尿酸可能具有保护作用，特别是对女性。
High levels of uric acid are associated with greater risk of stress-related cardiovascular illnesses that occur disproportionately among African Americans. Whether hyperuricemia affects biological response to acute stress remains largely unknown, suggesting a need to clarify this potential connection. The current study examined how salivary uric acid (sUA) is associated with resting and reactive blood pressure – two robust predictors of hypertension and related cardiovascular disease and disparity. Healthy African Americans (N= 107; 32% male;Mage = 31.74 years), completed the Trier Social Stress Test to induce social-evaluative stress. Systolic and diastolic blood pressure readings were recorded before, during, and after the task to assess resting and reactive change in blood pressure. Participants also provided a saliva sample at baseline that was assayed for sUA. At rest, and controlling for age, sUA was modestly associated with higher systolic (r= .201,p= .044), but not diastolic (r= .100,p= .319) blood pressure. In response to the stressor task, and once again controlling for age, sUA was also associated with higher total activation of both systolic (r= .219,p= .025) and diastolic blood pressure (r= .198,p< .044). A subsequent moderation analysis showed that associations between sUA and BP measures were significant for females, but not for males. Findings suggest that uric acid may be implicated in hypertension and cardiovascular health disparities through associations with elevated blood pressure responses to acute social stress, and that low levels of uric acid might be protective, particularly for females.