STIMULATION OF THE PERIAQUEDUCTAL GRAY-MATTER INHIBITS NOCICEPTION AT THE SUPRASPINAL AS WELL AS SPINAL LEVEL
STIMULATION OF THE PERIAQUEDUCTAL GRAY-MATTER INHIBITS NOCICEPTION AT THE SUPRASPINAL AS WELL AS SPINAL LEVEL
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DOI：
10.1016/0006-8993(89)90461-7
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发表时间：
1989-11-13
期刊：
影响因子：
2.9
通讯作者：
LIEBESKIND, JC
中科院分区：
文献类型：
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作者：
MORGAN, MM;SOHN, JH;LIEBESKIND, JC
已知对导水管周围灰质（PAG）的刺激调节脊髓水平的伤害性感受。一些研究表明，伤害性感受也可能通过PAG的上行投射来调节。为了研究这一假设，在28只大鼠的PAG尾侧立即选择性地破坏下行通路。另外28只大鼠作为非损伤对照。所有动物均在PAG中长期植入刺激电极，并使用涉及脊髓和棘上介导反应的试验（分别为甩尾和热板试验）评估抗伤害感受。在甩尾试验中，损伤大鼠比非损伤大鼠显着较少显示刺激产生的镇痛（SPA）（分别为28只中的4只和28只中的14只）。相比之下，在热板试验中，损伤和非损伤大鼠之间发生SPA的发生率无显著差异。这些发现表明，伤害性感受可以调制在脊髓上，以及脊髓，水平。
Stimulation of the periaqueductal gray matter (PAG) is known to modulate nociception at the spinal level. Several studies have suggested that nociception may also be modulated via ascending projections from the PAG. To study this hypothesis, the descending pathway was selectively disrupted immediately caudal to the PAG in 28 rats. Twenty-eight additional rats served as non-lesioned controls. All animals were chronically implanted with a stimulating electrode in the PAG, and antinociception was assessed using tests involving spinally and supraspinally mediated responses (tail-flick and hot-plate tests, respectively). Significantly fewer lesioned than non-lesioned rats showed stimulation-produced analgesia (SPA) in the tail-flick test (4 of 28 vs 14 of 28, respectively). In contrast, no significant difference in the incidence of SPA occurred between lesioned and non-lesioned rats in the hot-plate test. These findings demonstrate that nociception can be modulated at the supraspinal, as well as spinal, level.