Serotonin-induced inhibition of locomotor rhythm of the rat isolated spinal cord is mediated by the 5-HT1 receptor class
Serotonin-induced inhibition of locomotor rhythm of the rat isolated spinal cord is mediated by the 5-HT1 receptor class
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DOI：
10.1098/rspb.1998.0542
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发表时间：
1998-11-07
影响因子：
4.7
通讯作者：
Nistri, A
中科院分区：
文献类型：
--
作者：
Beato, M;Nistri, A
神经递质5-羟色胺(5-羟色胺)在体外诱导新生大鼠脊髓节律性运动模式(虚构运动)，这是研究仅在脊髓水平上运动程序产生的有用的实验模型。然而，5-羟色胺减缓了通常由激活NMDA谷氨酸受体引起的虚构运动，这表明这种单胺的复杂作用。通过对多根腹根的电生理记录，我们证明了5-羟色胺对NMDA诱发的周期的抑制是密切相关的，在药物阻断5-HT2兴奋性受体后增强，并被5-HT1受体家族的药理激动剂所模仿。5-HT1a或5-HT1B/D受体的选择性阻断剂单独或联合使用可显著(但不完全)减弱5-HT1或5-HT1B/D受体对脊髓运动网络的抑制作用。结论：5-羟色胺对脊髓运动网络的主要抑制作用是由5-HT1受体的某些亚型介导的，而5-HT2受体对脊髓运动网络的兴奋与5-HT2受体介导的兴奋相反。
The neurotransmitter serotonin (5-HT) induces rhythmic motor patterns (fictive locomotion) of the neonatal rat spinal cord in vitro; this is a useful experimental model to study the generation of a motor programme at exclusively spinal level. Nevertheless, 5-HT slows down the fictive locomotion typically elicited by activation of NMDA glutamate receptors, suggesting a complex action of this monoamine. By means of electrophysiological recordings from multiple ventral roots we demonstrated that the decrease caused by 5-HT in NMDA-induced periodicity was close-dependent, enhanced after pharmacological blocking of 5-HT2 excitatory receptors, and imitated by pharmacological agonists of the 5-HT1 receptor family. Selective blockers of the 5 -HT1A or 5-HT1B/D receptor classes, either alone or in combination, largely (but not completely) attenuated this inhibitory action of 5-HT It is concluded that the principal inhibitory action of 5-HT on the spinal locomotor network was mediated by certain subtypes of the 5-HT1 receptor class, which tends to oppose the 5-HT2 receptor-mediated excitation of the same network.