Three new labdane diterpenes from Loxocalyx urticifolius
Three new labdane diterpenes from Loxocalyx urticifolius
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DOI：
10.1016/j.phytol.2016.11.010
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发表时间：
2017-03
影响因子：
1.7
通讯作者：
Min Zhao;D. Guo;Lv-Yi Yuan;Yucheng Gu;Lei Chen;L. Ding;Yan Zhou
中科院分区：
文献类型：
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作者：
Min Zhao;D. Guo;Lv-Yi Yuan;Yucheng Gu;Lei Chen;L. Ding;Yan Zhou
从Loxocalyx urticifolius Hemsl全草中分离得到3种新的拉丹烷二萜，即loxocalyxin D (1)、loxocalyxin E (2)和13-epiloxocalyxin E (3)。通过广泛的光谱分析和化学方法阐明了它们的结构。通过 X 射线晶体学分析证实了 loxocalyxin D (1) 的绝对构型。评估了分离的拉丹丹二萜对四种人类癌细胞系 A549、HepG2、HL-60 和 MCF-7 的细胞毒活性。 13-epiloxocalyxin E (3) 对 A549 和 MCF-7 表现出选择性细胞毒性，IC50 值分别为 22.4 和 47.3 μM。
Three new labdane diterpenes, namely loxocalyxin D (1), loxocalyxin E (2) and 13-epiloxocalyxin E (3), were isolated from the whole plants ofLoxocalyx urticifoliusHemsl. Their structures were elucidated by extensive spectral analysis and chemical methods. The absolute configuration of loxocalyxin D (1) was confirmed by X-ray crystallographic analysis. The cytotoxic activities of the isolated labdane diterpenes were evaluated against the four human cancer cell lines A549, HepG2, HL-60 and MCF-7. 13-epiloxocalyxin E (3) exhibited selective cytotoxicity against A549 and MCF-7 with the IC50values of 22.4 and 47.3 μM, respectively.