Regulation of inducible gene expression by the transcription factor NF-κB
Regulation of inducible gene expression by the transcription factor NF-κB
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DOI：
10.1007/bf02786486
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发表时间：
1999-01-01
影响因子：
4.4
通讯作者：
Ghosh, S
中科院分区：
文献类型：
--
作者：
Ghosh, S
转录因子NF-κ B在调节免疫应答中的诱导基因表达中起关键作用。NF-κ B的激活在多个水平上受到调节，这可能反映了需要保持对其活性的严格控制。我们最近发现NF-κ B B自身的直接磷酸化对其转录活性是必需的，并且磷酸化作为一个开关来决定核NF-κ B B与组蛋白乙酰化酶或去乙酰化酶的关联。
The transcription factor NF-kappa B plays a critical role in regulating inducible gene expression in immune responses. The activation of NF-kappa B is regulated at multiple levels, probably reflecting a need to maintain a tight control of its activity. We have recently discovered that direct phosphorylation of NF-kappa B itself is essential for its transcriptional activity and that phosphorylation acts as a switch to determine association of nuclear NF-kappa B with histone acetylases vs deacetylases.