Gold-Catalyzed Synthesis of Carbon-Bridged Medium-Sized Rings
Gold-Catalyzed Synthesis of Carbon-Bridged Medium-Sized Rings
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DOI：
10.1021/ol901722q
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发表时间：
2009-09-17
期刊：
影响因子：
5.2
通讯作者：
Barriault, Louis
中科院分区：
文献类型：
--
作者：
Barabe, Francis;Betournay, Genevieve;Barriault, Louis
双环[m.n.1]烯酮骨架具有与桥连酮相邻的季碳中心，经常发现于生物活性天然产物中。虽然已经开发了几种方法来构建这样的框架，但它们中的大多数都是特定于特定支架的。在此，我们报道了一种温和而高效的方法，使用膦基金（I）催化剂生成各种尺寸的碳桥骨架。
Bicyclo[m.n.1]alkenone frameworks possessing quaternary carbon centers adjacent to a bridged ketone are frequently found in bioactive natural products. Although several methods have been developed to construct such frameworks, most of them are specific to a particular scaffold. Herein, we report a mild and highly efficient method to generate carbon-bridged frameworks of various sizes using phosphino gold(I) catalysts.