Influences of AT1 receptor blockade on tissue metabolism in obese men.
Influences of AT1 receptor blockade on tissue metabolism in obese men.
复制标题
AT1 受体阻断对肥胖男性组织代谢的影响。
DOI：
--
复制
发表时间：
2006
期刊：
影响因子：
--
通讯作者：
J. Jordan
中科院分区：
文献类型：
--
作者：
M. Boschmann;S. Engeli;F. Adams;Gabriele Franke;F. Luft;Arya M. Sharma;J. Jordan
ANG II applied to the interstitial space influences carbohydrate and lipid metabolism in a tissue-specific fashion. Thus endogenous ANG II may have a tonic effect on tissue metabolism that could be reversed with ANG II type 1 (AT1) receptor blockade, particularly during adrenergic stimulation. We studied 14 obese men. They were treated for 10 days with the AT1 receptor blocker irbesartan or with placebo in a double-blind and crossover fashion. At the end of each treatment period, we assessed skeletal muscle and adipose tissue metabolism using the microdialysis technique. The ethanol dilution technique was applied to follow changes in tissue blood flow. Measurements were obtained at baseline and during application of incremental isoproterenol concentrations through the microdialysis catheter. Blood pressure decreased from 133 +/- 3/84 +/- 3 to 128 +/- 3/79 +/- 2 mmHg for systolic and diastolic blood, respectively (P = 0.02 and 0.006, respectively) with AT1 receptor blockade. Isoproterenol perfusion caused a dose-dependent increase in dialysate glycerol in adipose tissue and in skeletal muscle. Irbesartan slightly reduced the isoproterenol-induced glycerol response in adipose tissue (P < 0.05 by ANOVA). Ethanol ratio, interstitial glucose supply, and lactate production in adipose tissue and skeletal muscle were similar with placebo and irbesartan. We conclude that AT1 receptor blockade in obese men does not reveal a major tonic ANG II effect on interstitial glucose supply, lipolysis, or glycolysis in skeletal muscle, either at rest or during beta-adrenergic stimulation. Endogeneous ANG II may slightly increase adipose tissue lipolysis. The mechanism may promote the redistribution of triglycerides from adipose tissue toward other organs.
棕色脂肪组织中内源性血管紧张素 II 对神经递质释放的突触前调节。
DOI：
10.1007/978-3-7091-9175-0_17
发表时间：
1991
期刊：
Journal of neural transmission. Supplementum
影响因子：
--
作者：
Cassis,LA;Dwoskin,LP
通讯作者：
Dwoskin,LP
cdx-2 和 HNF-1alpha 控制 Caco-2 细胞中分化诱导的 calbindin-D9k 基因表达。
DOI：
10.1152/ajpgi.00121.2004
发表时间：
2004
期刊：
American journal of physiology. Gastrointestinal and liver physiology
影响因子：
--
作者：
Wang,Liyong;Klopot,Anna;Freund,Jean-Noel;Dowling,LaurenN;Krasinski,StephenD;Fleet,JamesC
通讯作者：
Fleet,JamesC