Experimental infection of alpine goats with a Moroccan strain of peste des petits ruminants virus (PPRV)
Experimental infection of alpine goats with a Moroccan strain of peste des petits ruminants virus (PPRV)
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DOI：
10.1016/j.vetmic.2012.04.043
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发表时间：
2012-11-09
影响因子：
3.3
通讯作者：
El Harrak, Mehdi
中科院分区：
文献类型：
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作者：
Hammouchi, Mustapha;Loutfi, Chafiqua;El Harrak, Mehdi
小反刍兽疫病毒（PPRV）最近在摩洛哥绵羊和山羊中引起了严重的疾病爆发。高山山羊对PPRV高度易感，死亡率接近100%，而当地品种的绵羊对该病的易感性较低。通过对PPRV摩洛哥株的实验感染研究，研究了高山山羊的相对易感性。在高山山羊中观察到严重的临床症状，病毒通过眼、鼻和口腔途径排出。在不同的接种途径下，观察到山羊的疾病严重程度没有差异，并证实了病毒通过直接接触传播。本研究证实了高山山羊对PPRV感染的易感性，并描述了一种挑战方案，该方案有效且一致地再现了实验感染山羊中PPR的严重临床体征。(C)2012爱思唯尔有限公司版权所有。
Peste des petits ruminants virus (PPRV) recently caused a serious outbreak of disease in Moroccan sheep and goats. Alpine goats were highly susceptible to PPRV with mortality rates approaching 100%, as opposed to local breeds of sheep which were less susceptible to the disease. The relative susceptibility of alpine goats was investigated through an experimental infection study with the Moroccan strain of PPRV. Severe clinical signs were observed in the alpine goats with virus being excreted through ocular, nasal and oral routes. No difference in the severity of the disease in goats was observed with different inoculation routes and transmission of the virus by direct contact was confirmed. This study confirmed the susceptibility of the alpine goat to PPRV infection and describes a challenge protocol that effectively and consistently reproduced severe clinical signs of PPR in experimentally infected goats. (C) 2012 Elsevier B.V. All rights reserved.